ASP 7663
Tocris Bioscience, part of Bio-Techne | Catalog # 5178
Selective TRPA1 activator
Product Description
ASP 7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat). Displays little or no affinity at more than 60 other related receptors, channels and enzymes. Stimulates 5-HT release from QGP-1 cells. Exhibits an abdominal analgesic effect in vivo. Orally bioavailable.Product Specifications
Molecular Weight
263.26
Formula
C14H14FNO3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid
CAS Number
1190217-35-6
PubChem ID
44232532
InChI Key
RCVZUIGCNAAMIC-UXBLZVDNSA-N
SMILES
O=C2/C(C1=CC=CC(F)=C1N2CC(C)C)=C/C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.33 | 100 | |
| Ethanol | 26.33 | 100 |
Preparing Stock Solutions
for ASP 7663
The following data is based on the product molecular weight 263.26
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.80 mL | 18.99 mL | 37.99 mL |
| 5 mM | 0.76 mL | 3.80 mL | 7.60 mL |
| 10 mM | 0.38 mL | 1.90 mL | 3.80 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kojima Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur.J.Pharmacol. 2014 PMID: 24291101
Product Specific Notices for ASP 7663
For research use only
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