URB 597
Tocris Bioscience, part of Bio-Techne | Catalog # 4612
Potent and selective FAAH inhibitor
Key Product Details
Description
Potent and selective FAAH inhibitor
Product Description
URB 597 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.Product Specifications
Molecular Weight
338.40
Formula
C20H22N2O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
Cyclohexylcarbamic acid 3'-(Aminocarbonyl)-[1,1'-biphenyl]-3-yl ester
CAS Number
546141-08-6
PubChem ID
1383884
InChI Key
ROFVXGGUISEHAM-UHFFFAOYSA-N
SMILES
NC(C1=CC(C2=CC=CC(OC(NC3CCCCC3)=O)=C2)=CC=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.92 | 50 |
Preparing Stock Solutions
for URB 597
The following data is based on the product molecular weight 338.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.91 mL | 29.55 mL | 59.10 mL |
| 2.5 mM | 1.18 mL | 5.91 mL | 11.82 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.91 mL |
| 25 mM | 0.12 mL | 0.59 mL | 1.18 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Piomelli Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 2006 PMID: 16834756
- Jayamanne Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br.J.Pharmacol. 2006 PMID: 16331291
- Hohmann An endocannabinoid mechanism for stress-induced analgesia. Nature 2005 PMID: 15973410
Product Specific Notices for URB 597
For research use only
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