Icilin

Tocris Bioscience, part of Bio-Techne | Catalog # 1531

Activates cold receptors. Cooling agent
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Key Product Details

Description

Activates cold receptors. Cooling agent

Alternative Names

AG 3-5

View all TRPA1 Agonists »

Product Description

Icilin is a cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures. Produces "wet shakes" in vivo.

Product Specifications

Molecular Weight

311.30

Formula

C16H13N3O4

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one

CAS Number

36945-98-9

PubChem ID

161930

InChI Key

RCEFMOGVOYEGJN-UHFFFAOYSA-N

SMILES

OC1=C(C=CC=C1)N1CC=C(NC1=O)C1=CC=CC(=C1)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.13 100

Preparing Stock Solutions for Icilin

The following data is based on the product molecular weight 311.30

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.21 mL 16.06 mL 32.12 mL
5 mM 0.64 mL 3.21 mL 6.42 mL
10 mM 0.32 mL 1.61 mL 3.21 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Icilin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Icilin

For research use only

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