HC 030031

Name: HC 030031
Brand: Tocris Bioscience
SKU: 2896
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2896

(2)

Citations (147)

COA / SDS

Selective TRPA1 blocker

Key Product Details

Description:	Selective TRPA1 blocker
Chemical Name:	2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	355.39

View Full Technical Details for HC 030031

Technical Data
Citations / Reviews (2)

Biological Activity for HC 030031

HC 030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx (IC₅₀ values are 6.2 and 5.3 μM respectively). Does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG or Na_V1.2 channels. Inhibits AITC- and formalin-induced flinching in vivo.

Compound Libraries for HC 030031

HC 030031 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for HC 030031

M. Wt	355.39
Formula	C₁₈H₂₁N₅O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	349085-38-7
PubChem ID	1150897
InChi Key	HEQDZPHDVAOBLN-UHFFFAOYSA-N
Smiles	O=C1C2=C(N=CN2CC(NC3=CC=C(C(C)C)C=C3)=O)N(C)C(N1C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for HC 030031

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.54	100

Preparing Stock Solutions for HC 030031

The following data is based on the product molecular weight 355.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.07 mL	28.14 mL
5 mM	0.56 mL	2.81 mL	5.63 mL
10 mM	0.28 mL	1.41 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for HC 030031

References are publications that support the biological activity of the product.

McNamara TRPA1 mediates formalin-induced pain. Proc.Natl.Acad.Sci.USA 2007 PMID: 17686976
Taylor-Clark Prostaglandin-induced activation of nociceptive neurons via direct interactions with TRPA1. Mol.Pharmacol. 2008 PMID: 18000030