TAG Degradation Platforms

dTAG^V-1

Catalog #: 6914

(2)

Citations (95)

Product Documents

Images (1)

Potent and selective degrader of mutant FKBP12F36V fusion proteins

Chemical Name:

(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate trifluoroacetate

Purity:

≥98%

dTAG-13

Catalog #: 6605

(4)

Citations (146)

Product Documents

Images (1)

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name:

1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester

Purity:

≥98%

dTAG^V-1-NEG

Catalog #: 6915

(1)

Citations (14)

Product Documents

Images (1)

Negative control for dTAGV-1 (Cat. No. 6914)

Chemical Name:

(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2R,4S)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Purity:

≥98%

5-Ph-IAA

Catalog #: 7392

Citations (12)

Product Documents

Images (1)

Selective and potent TAG Degrader for auxin-inducible degron 2 system

Chemical Name:

5-Phenyl-1H-indole-3-acetic acid

Purity:

≥98%

dTAG-13-NEG

Catalog #: 6916

Citations (4)

Product Documents

Images (1)

Negative control for dTAG-13 (Cat. No. 6605)

Chemical Name:

1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester

Purity:

≥97%

dTAG-47

Catalog #: 7530

Citations (4)

Product Documents

Images (1)

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name:

(1R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Purity:

≥97%

aTAG 4531

Catalog #: 6971

Citations (1)

Product Documents

Images (1)

Degrader of MTH1 fusion proteins for use within the aTAG system

Alternate Names:

CFT 4531

Chemical Name:

N-Cyclopropyl-6-(4-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)butyl)carbamoyl)-3-fluorophenyl)-7-fluoro-4-(phenylamino)quinoline-3-carboxamide

Purity:

≥98%

dTAG-7

Catalog #: 6912

Citations (11)

Product Documents

Images (1)

First generation Degrader for mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name:

(1R)-3-(3,4-Dimethoxyphenyl)-1-(2-((19-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadecyl)oxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Purity:

≥98%

dTAG^V-1 hydrochloride

Catalog #: 7374

(1)

Citations (3)

Product Documents

Images (1)

Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use

Chemical Name:

(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate hydrochloride

Purity:

≥98%

dTAG-47-NEG

Catalog #: 7531

Product Documents

Images (1)

Negative control for dTAG-47 (Cat. No. 7530)

Chemical Name:

(1R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((8-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Purity:

≥97%

AP 1867

Catalog #: 6207

Product Documents

Images (1)

Selective binding ligand for FKBP12F36V

Chemical Name:

(1R)-1-[3-(Carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate

Purity:

≥98%

aTAG 2139

Catalog #: 6970

Citations (1)

Product Documents

Images (1)

Degrader of MTH1 fusion proteins for use within the aTAG system

Alternate Names:

CFT 2139

Chemical Name:

6-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)pyridin-3-yl)-N-methyl-4-(phenylamino)quinoline-3-carboxamide

Purity:

≥98%

aTAG 2139-NEG

Catalog #: 7575

Product Documents

Images (1)

Negative control for aTAG 2139 (Cat. No. 6970)

Chemical Name:

6-(6-((4-(2-((2-(1-Methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)pyridin-3-yl)-N-methyl-4-(phenylamino)quinoline-3-carboxamide

Purity:

≥98%

XY-06-007

Catalog #: 7669

Product Documents

Images (1)

Potent and selective Degrader of Brd4BD1 L94V fusion proteins

Chemical Name:

(2R)-2-((S)-6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-(5-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)pentyl)propanamide

Purity:

≥98%

BromoTag^® AGB1

Catalog #: 7686

Citations (12)

Product Documents

Images (2)

Potent and selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)

Chemical Name:

(S)-13-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl (R)-2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)butanoate

Purity:

≥98%

aTAG 2139-NEG

Catalog #: 7575

Product Documents

Images (1)

Negative control for aTAG 2139 (Cat. No. 6970)

Chemical Name:

6-(6-((4-(2-((2-(1-Methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)carbamoyl)pyridin-3-yl)-N-methyl-4-(phenylamino)quinoline-3-carboxamide

Purity:

≥98%

BromoTag^® AGB3

Catalog #: 7688

Product Documents

Images (1)

Selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)

Chemical Name:

(2S,4R)-1-((2S,17R)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazanonadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity:

≥98%

Ortho AP 1867

Catalog #: 7787

Product Documents

Images (1)

Selective binding ligand for FKBP12F36V; precursor for dTAG compounds

Chemical Name:

2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid

Purity:

≥98%

dTAG-Biotin

Catalog #: 7883

Product Documents

Images (1)

Affinity probe for mutant FKBP12F36V proteins

Chemical Name:

(R)-3-(3,4-Dimethoxyphenyl)-1-(2-((2,16-dioxo-20-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-6,9,12-trioxa-3,15-diazaicosyl)oxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Purity:

≥98%

dTAG-Fluorescein

Catalog #: 7892

Product Documents

Images (1)

Fluorescent probe for labeling mutant FKBP12 (F36V) proteins

Chemical Name:

(R)-1-(2-(2-((3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthen]-5-yl)amino)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Purity:

≥95%

5-Ph-IAA-AM

Catalog #: 7893

Citations (2)

Product Documents

Images (1)

Selective and potent TAG Degrader for auxin-inducible degron 2 system; 5-Ph-IAA analog

Chemical Name:

Acetoxymethyl 2-(5-phenyl-1H-indol-3-yl)acetate

Purity:

≥98%

dTAG Janelia Fluor^® 635

Catalog #: 8101

Product Documents

Images (3)

Fluorogenic srTAG probe for live cell imaging of FBKP12 (F36V/L) fusion proteins

Chemical Name:

4-((2-(2-(3-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetamido)ethyl)carbamoyl)-2-(3-(3-fluoroazetidin-1-ium-1-ylidene)-7-(3-fluoroazetidin-1-yl)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)benzoate

Purity:

≥95%

dTAG Janelia Fluor^® 525

Catalog #: 8102

Product Documents

Images (1)

Fluorogenic srTAG probe for live cell imaging of FBKP12 (F36V/L) fusion proteins

Chemical Name:

2-(3-(3,3-Difluoroazetidin-1-ium-1-ylidene)-6-(3,3-difluoroazetidin-1-yl)-3H-xanthen-9-yl)-4-((2-(2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetamido)ethyl)carbamoyl)benzoate

Purity:

≥95%

dTAG Janelia Fluor^® 585

Catalog #: 8103

Product Documents

Images (1)

Fluorogenic srTAG probe for live cell imaging of FKBP12(F36V/L) fusion proteins

Chemical Name:

2-(3-(3,3-Difluoroazetidin-1-ium-1-ylidene)-6-(3,3-difluoroazetidin-1-yl)-10,10-dimethyl-3,10-dihydroanthracen-9-yl)-4-((2-(2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetamido)ethyl)carbamoyl)benzoate

Purity:

≥95%

dTAG Janelia Fluor^® 585

Catalog #: 8103

Product Documents

Images (1)

Fluorogenic srTAG probe for live cell imaging of FKBP12(F36V/L) fusion proteins

Chemical Name:

2-(3-(3,3-Difluoroazetidin-1-ium-1-ylidene)-6-(3,3-difluoroazetidin-1-yl)-10,10-dimethyl-3,10-dihydroanthracen-9-yl)-4-((2-(2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetamido)ethyl)carbamoyl)benzoate

Purity:

≥95%

TAG Degradation Platforms

dTAG^V-1

dTAG-13

dTAG^V-1-NEG

5-Ph-IAA

dTAG-13-NEG

dTAG-47

aTAG 4531

dTAG-7

dTAG^V-1 hydrochloride

dTAG-47-NEG

AP 1867

aTAG 2139

aTAG 2139-NEG

XY-06-007

BromoTag^® AGB1

aTAG 2139-NEG

BromoTag^® AGB3

Ortho AP 1867

dTAG-Biotin

dTAG-Fluorescein

5-Ph-IAA-AM

dTAG Janelia Fluor^® 635

dTAG Janelia Fluor^® 525

dTAG Janelia Fluor^® 585

dTAG Janelia Fluor^® 585

CONTACT INFORMATION

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TAG Degradation Platforms

dTAGV-1

dTAG-13

dTAGV-1-NEG

5-Ph-IAA

dTAG-13-NEG

dTAG-47

aTAG 4531

dTAG-7

dTAGV-1 hydrochloride

dTAG-47-NEG

AP 1867

aTAG 2139

aTAG 2139-NEG

XY-06-007

BromoTag® AGB1

aTAG 2139-NEG

BromoTag® AGB3

Ortho AP 1867

dTAG-Biotin

dTAG-Fluorescein

5-Ph-IAA-AM

dTAG Janelia Fluor® 635

dTAG Janelia Fluor® 525

dTAG Janelia Fluor® 585

dTAG Janelia Fluor® 585

dTAG^V-1

dTAG^V-1-NEG

dTAG^V-1 hydrochloride

BromoTag^® AGB1

BromoTag^® AGB3

dTAG Janelia Fluor^® 635

dTAG Janelia Fluor^® 525

dTAG Janelia Fluor^® 585

dTAG Janelia Fluor^® 585