dTAG-Biotin
Tocris Bioscience, part of Bio-Techne | Catalog # 7883
Affinity probe for mutant FKBP12F36V proteins
Key Product Details
Description
Affinity probe for mutant FKBP12F36V proteins
Product Description
dTAG-Biotin is an affinity probe for mutant FKBP12F36V proteins. Comprises the ligand ortho-AP1867, selective for F36V single-point mutated FKBP12, joined by a PEG3 linker to biotin. It can be used for chemical biology studies such as proteomics, enrichment studies, dimerization experiments, and assay validation.Product Specifications
Molecular Weight
1094.33
Formula
C56H79N5O15S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(R)-3-(3,4-Dimethoxyphenyl)-1-(2-((2,16-dioxo-20-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-6,9,12-trioxa-3,15-diazaicosyl)oxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
InChI Key
ZUFVYPUCFFRQTG-ZFJGIIHNSA-N
SMILES
CC[C@@H](C1=CC(OC)=C(C(OC)=C1)OC)C(N2CCCC[C@H]2C(O[C@@H](C3=CC=CC=C3OCC(NCCOCCOCCOCCNC(CCCC[C@@H]4SC[C@@](N5)([H])[C@]4([H])NC5=O)=O)=O)CCC6=CC(OC)=C(C=C6)OC)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 109.43 | 100 |
Preparing Stock Solutions
for dTAG-Biotin
The following data is based on the product molecular weight 1094.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.91 mL | 4.57 mL | 9.14 mL |
| 5 mM | 0.18 mL | 0.91 mL | 1.83 mL |
| 10 mM | 0.09 mL | 0.46 mL | 0.91 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.18 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nabet The dTAG system for immediate and target-specific protein degradation. Nat.Chem.Biol. 2018 PMID: 29581585
Product Specific Notices for dTAG-Biotin
For research use only
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