Ortho AP 1867
Tocris Bioscience, part of Bio-Techne | Catalog # 7787
Selective binding ligand for FKBP12F36V; precursor for dTAG compounds
Key Product Details
Description
Selective binding ligand for FKBP12F36V; precursor for dTAG compounds
Product Description
Ortho AP 1867 is a selective binding ligand for the single point mutant of FKBP12F36V. Functionalized with a carboxylic acid group in the ortho-position to enable onward chemistry. The position of the carboxylic acid group represents an 'exit vector' allowing modification without interfering with compound binding ability. Ortho AP 1867 is a precursor for the dTAG compounds.Product Specifications
Molecular Weight
693.79
Formula
C38H47NO11
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid
CAS Number
2230613-03-1
PubChem ID
133080821
InChI Key
UYXSZUBFOQLRNQ-BTIIJPOSSA-N
SMILES
CC[C@@H](C1=CC(OC)=C(C(OC)=C1)OC)C(N2CCCC[C@H]2C(O[C@@H](C3=CC=CC=C3OCC(O)=O)CCC4=CC(OC)=C(C=C4)OC)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 69.38 | 100 |
Preparing Stock Solutions
for Ortho AP 1867
The following data is based on the product molecular weight 693.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.44 mL | 7.21 mL | 14.41 mL |
| 5 mM | 0.29 mL | 1.44 mL | 2.88 mL |
| 10 mM | 0.14 mL | 0.72 mL | 1.44 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.29 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nabet The dTAG system for immediate and target-specific protein degradation. Nat.Chem.Biol. 2018 PMID: 29581585
Product Specific Notices for Ortho AP 1867
For research use only
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