9 results for "STING-dependent Signaling Agonists Small Molecules and Peptides" in Products
STING-dependent Signaling Agonists: Small Molecules and Peptides
STING (stimulator of interferon genes) is a pattern recognition receptor and adapter protein that is anchored in the endoplasmic reticulum (ER), and is highly expressed in immune cells. STING-dependent signaling mediates a Toll-like receptor independent innate immune response following detection of cytoplasmic pathogens.
The invasion of a cell by a pathogen, such as a virus or bacterium, results in a host defence response mediated by the adapter protein STING. Foreign DNA is detected by ...
Endogenous high affinity STING agonist
| Chemical Name: | 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt |
| Purity: | ≥98% (HPLC) |
Pan-polymorph STING agonist
| Chemical Name: | 1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1H-indole-6-carboxamide |
| Purity: | ≥98% (HPLC) |
Non-nucleotide STING agonist; orally bioavailable
| Chemical Name: | 4-(5,6-Dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid |
| Purity: | ≥98% (HPLC) |
Endogenous STING and DDX41 agonist; activates STING-dependent signaling
| Chemical Name: | 3',5'-Cyclic diguanylic acid sodium salt |
| Purity: | ≥98% (HPLC) |
mSTING agonist; induces antitumor immunological responses
| Chemical Name: | 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid |
| Purity: | ≥98% (HPLC) |
STING agonist
| Chemical Name: | [P(R)]-5'-O-[(R)-Hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-adenosine cyclic nucleotide disodium |
| Purity: | ≥95% (HPLC) |
Murine-selective STING agonist
| Chemical Name: | 9-Oxo-10(9H)-acridineacetic acid |
| Purity: | ≥98% (HPLC) |
STING agonist, molecular glue that causes oligomerization of STING
| Chemical Name: | 4-((4-(2-(tert-Butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid |
| Purity: | ≥98% (HPLC) |
Induces expression of STING and STING-related genes; antiviral
| Chemical Name: | 3',2'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt |
| Purity: | ≥98% (HPLC) |
