13 results for "p53 Small Molecules and Peptides" in Products
p53 Small Molecules and Peptides
p53 is well known for its key role as a tumor suppressor protein. It is 393 amino acids (aa) in length with a predicted molecular weight of 44 kDa. It belongs to the p53 family that also includes p63 and p73. Structurally, p53 is characterized by an N-terminal transactivation domain, central DNA-binding and oligomerization domains, and a C-terminal regulatory domain. It is thought to exist as a homotetramer, and it exhibits approximately 72% and 76% aa identity with its mouse and rat ...
Restores mutant p53 activity; proapoptotic
Restores mutant p53 activity
MDM2 antagonist; inhibits MDM2-p53 interaction
p53 inhibitor. Also aryl hydrocarbon receptor agonist
Potent and selective allosteric inhibitor of Wip1 phosphatase
p53 inhibitor
Hdm2 inhibitor; activates p53-dependent transcription
MDM2-p53 interaction inhibitor
Cyclooxygenase inhibitor; NSAID
MDM2-p53 interaction inhibitor
RNA polymerase I inhibitor; also p53 pathway activator
Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
RNA polymerase I inhibitor; also p53 pathway activator