MIRA-1

Name: MIRA-1
Brand: Tocris Bioscience
SKU: 3362

Catalog # 3362 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Restores mutant p53 activity; proapoptotic

Key Product Details

Description:	Restores mutant p53 activity; proapoptotic
Chemical Name:	1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione
Molecular Weight:	183.16

View Full Technical Details for MIRA-1

Technical Data
Citations (1) / Reviews

Biological Activity for MIRA-1

MIRA-1 is a restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC₅₀ = 10μM).

Technical Data for MIRA-1

M. Wt	183.16
Formula	C₈H₉NO₄
Storage	Store at +4°C
CAS Number	72835-26-8
PubChem ID	227681
InChi Key	YXEWPGYLMHXLPS-UHFFFAOYSA-N
Smiles	O=C(N1COC(CC)=O)C=CC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MIRA-1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	18.32	100
	ethanol	18.32	100

Preparing Stock Solutions for MIRA-1

The following data is based on the product molecular weight 183.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.46 mL	27.30 mL	54.60 mL
5 mM	1.09 mL	5.46 mL	10.92 mL
10 mM	0.55 mL	2.73 mL	5.46 mL
50 mM	0.11 mL	0.55 mL	1.09 mL

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References for MIRA-1

References are publications that support the biological activity of the product.

Kumar p53 in breast cancer: mutation and countermeasures. Front.Biosci. 2007 PMID: 17485365
Wiman Strategies for therapeutic targeting of the p53 pathway in cancer. Cell Death Differ. 2006 PMID: 16557267
Bykov Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. J.Biol.Chem. 2005 PMID: 15998635

Citations for MIRA-1 (1)

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Citations are publications that use Bio-Techne products. Selected citations for MIRA-1 include:

Saha et al. (2014) Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents. Br J Cancer. 110:2224
PMID: 24691427

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