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p38 delta Products
The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses. All four p38 family members, alpha, beta, gamma, and delta, are phosphorylated by MKK3 and/or MKK6 at dual Thr and Tyr positions within the phosphoacceptor sequence Thr-Gly-Tyr. Once activated, p38 phosphorylates a number of targets, including the nuclear transcription factors ATF2 and Max.
The most frequently analyzed family member, p38 alpha, also known as SAPK2a and MAPK14, was initially purified as a kinase critical to the signaling cascade linking IL-1 to MAPKAPK-2 and the small heat shock protein HSP27. Ubiquitously expressed, p38 alpha is dually phosphorylated by MKK3 and MKK6 at Thr180 and Tyr182. Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. Several promising compounds that inhibit p38 alpha are being investigated as potential therapies for arthritic and inflammatory diseases.
11 results for "p38 delta" in Products
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p38 delta Products
The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses. All four p38 family members, alpha, beta, gamma, and delta, are phosphorylated by MKK3 and/or MKK6 at dual Thr and Tyr positions within the phosphoacceptor sequence Thr-Gly-Tyr. Once activated, p38 phosphorylates a number of targets, including the nuclear transcription factors ATF2 and Max.
The most frequently analyzed family member, p38 alpha, also known as SAPK2a and MAPK14, was initially purified as a kinase critical to the signaling cascade linking IL-1 to MAPKAPK-2 and the small heat shock protein HSP27. Ubiquitously expressed, p38 alpha is dually phosphorylated by MKK3 and MKK6 at Thr180 and Tyr182. Once activated, p38 alpha phosphorylates a number of targets, including the cytoplasmic kinases MNK 4 and PRAK5 and the nuclear transcription factors ATF2 1 and STAT1. Several promising compounds that inhibit p38 alpha are being investigated as potential therapies for arthritic and inflammatory diseases.
11 results for "p38 delta" in Products
Natural cannabinoid; GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist and AMT inhibitor
| Alternate Names : | CBD |
| Chemical Name : | 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol |
| Purity : | ≥99% (HPLC) |
Selective inhibitor of p38 MAPK
| Chemical Name : | 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine |
| Purity : | ≥98% (HPLC) |
Potent, selective inhibitor of MEK1 and 2
| Chemical Name : | 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene |
Selective inhibitor of TGF-βRI
| Alternate Names : | HTS 466284 |
| Chemical Name : | 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline |
| Purity : | ≥99% (HPLC) |
| Clonality : | Polyclonal |
| Host : | Rabbit IgG |
| Applications : | Immunohistochemistry, Western Blot |
High affinity and selective p38 kinase inhibitor
| Alternate Names : | Doramapimod |
| Chemical Name : | N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea |
| Purity : | ≥98% (HPLC) |
Potent and selective p38δ PROTAC®
| Chemical Name : | N-(3-Fluoro-4-((7-(2-(2-(2-(2-(((2S,4R)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)ethoxy)ethoxy)ethoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide |
| Purity : | ≥98% (HPLC) |
Src family kinase inhibitor; also inhibits c-Abl
| Alternate Names : | 1-NA-PP 1 |
| Chemical Name : | 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity : | ≥99% (HPLC) |
Selective MEK inhibitor
| Alternate Names : | CI-1040 |
| Chemical Name : | 2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide |
p38 MAPK inhibitor
| Chemical Name : | N-Cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine |
| Purity : | ≥98% (HPLC) |
Potent and highly selective α2 agonist
| Chemical Name : | 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride |
| Purity : | ≥99% (HPLC) |
