SJFδ
Tocris Bioscience, part of Bio-Techne | Catalog # 7267
Potent and selective p38δ PROTAC®
Product Description
SJFδ is a potent and selective PROTAC ® Degrader of p38δ (DC50 = 46.17 nM; Dmax = 99.41%). SJFδ comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Exhibits no significant degradation of p38α, β or γ. Selectively degrades p38δ in MDA-MB-231 cells.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
1168.28
Formula
C62H63F2N7O12S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(3-Fluoro-4-((7-(2-(2-(2-(2-(((2S,4R)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)ethoxy)ethoxy)ethoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CAS Number
2254609-23-7
PubChem ID
137628678
InChI Key
LYUUIIZKBMBNQV-CHOFKVETSA-N
SMILES
COC1=CC2=C(C=C1OCCOCCOCCOC1=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@H](C(C)C)N3CC4=CC=CC=C4C3=O)C=CC(=C1)C1=C(C)N=CS1)N=CC=C2OC1=C(F)C=C(NC(=O)C2(CC2)C(=O)NC2=CC=C(F)C=C2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.41 | 50 |
Preparing Stock Solutions
for SJFδ
The following data is based on the product molecular weight 1168.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 1.71 mL | 8.56 mL | 17.12 mL |
| 2.5 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 5 mM | 0.17 mL | 0.86 mL | 1.71 mL |
| 25 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Smith Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat.Commun. 2019 PMID: 30631068
Product Specific Notices for SJFδ
For research use only
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