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U0126

Tocris Bioscience a Bio-Techne Brand

U0126 | CAS No. 109511-58-2 | Potent, selective inhibitor of MEK1 and 2
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Key Product Details

Description: Potent, selective inhibitor of MEK1 and 2
Chemical Name: 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
Molecular Weight: 380.48

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Citations for U0126 (131)

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Customer Reviews for U0126 (3)

4.7 out of 5
3 customer ratings
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  • Used to block MEK signaling.
    Name: MARINA KOUTSIOUMPA
    Species: Human
    Assay Type: In Vitro
    Pancreatic cancer cells were pretreated for 2 hours with U0126 followed by conventional chemotherapeutics. MEK inhibition had an additive effect on cancer cell’s viability upon 3 days of treatment.
  • Used for Migration assays
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: A549 or MDAMB231
    All MAPK inhibitors (ZM336372: c-RAF inhibitor; UO126: MEK1/MEK2 inhibitor, SB203580: p38 inhibitor) were used at 10 μM
    We ordered this product, combining with another inhibitor, to confirm the migration.To confirm that tested product induces migration, we also screen all MAPK inhibitors and MIF receptor antagonists
    U0126 Serum 1144
  • Effect of MEK inhibitor on E0771 extracellular flux
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: E0771
    Extracellular flux analysis (Seahorse experiment) to examine the effect of MEK inhibitor in breast cancer cells. 5-10uM dose used.

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Product Documents for U0126

Certificate of Analysis

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