U0126

Tocris Bioscience, part of Bio-Techne | Catalog # 1144

Potent, selective inhibitor of MEK1 and 2
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Key Product Details

Description

Potent, selective inhibitor of MEK1 and 2

View all MEK Inhibitors »

Product Description

U0126 is a potent and selective non-competitive inhibitor of MAP kinase kinase. Inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Brain penetrant. Helps maintain human pluripotent stem cells in undifferentiated state.

Negative Control also available.

Product Specifications

Molecular Weight

380.48

Formula

C18H16N6S2

Storage

Desiccate at +4°C

Chemical Name

1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene

CAS Number

109511-58-2

PubChem ID

3006531

InChI Key

DVEXZJFMOKTQEZ-JYFOCSDGSA-N

SMILES

N\C(SC1=CC=CC=C1N)=C(C#N)/C(C#N)=C(\N)SC1=CC=CC=C1N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.05 100

Preparing Stock Solutions for U0126

The following data is based on the product molecular weight 380.48

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.14 mL 26.28 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for U0126

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for U0126

For research use only

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