SB 706504

Name: SB 706504
Brand: Tocris Bioscience
SKU: 5040

Tocris Bioscience a Bio-Techne Brand

Catalog # 5040

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Key Product Details

Description:	p38 MAPK inhibitor
Chemical Name:	N-Cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine
Purity:	≥98% (HPLC)
Molecular Weight:	492.46

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Biological Activity for SB 706504

SB 706504 is a p38 MAPK inhibitor. Inhibits LPS-induced transcription of a range of chemokines and cytokines in chronic obstructive pulmonary disease (COPD) monocyte derived macrophages (MDMs). Also inhibits LPS-induced protein expression of IL-6, IL-10, TNFα and γ-inducible protein 10 in COPD MDMs. Effects on suppression of LPS-induced gene and protein expression are enhanced in combination with dexamethasone (Cat. No. 1126).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries for SB 706504

SB 706504 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SB 706504

M. Wt	492.46
Formula	C₂₄H₁₉F₃N₈O
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	911110-38-8
PubChem ID	11853799
InChi Key	ZQFBVJBAWLZLOM-UHFFFAOYSA-N
Smiles	N=C(NC#N)NCCNC1=NC(C4=C(C)C=C(F)C=C4)=C(C=CC(N2C3=C(F)C=CC=C3F)=O)C2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 706504

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.25	100

Preparing Stock Solutions for SB 706504

The following data is based on the product molecular weight 492.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.03 mL	10.15 mL	20.31 mL
5 mM	0.41 mL	2.03 mL	4.06 mL
10 mM	0.20 mL	1.02 mL	2.03 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for SB 706504

References are publications that support the biological activity of the product.

Kent Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexameth. and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl) J.Pharmacol.Exp.Ther. 2009 PMID: 19004925

Citations for SB 706504

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