SB 706504
Tocris Bioscience, part of Bio-Techne | Catalog # 5040
p38 MAPK inhibitor
Product Description
SB 706504 is a p38 MAPK inhibitor. Inhibits LPS-induced transcription of a range of chemokines and cytokines in chronic obstructive pulmonary disease (COPD) monocyte derived macrophages (MDMs). Also inhibits LPS-induced protein expression of IL-6, IL-10, TNFα and γ-inducible protein 10 in COPD MDMs. Effects on suppression of LPS-induced gene and protein expression are enhanced in combination with dexamethasone (Cat. No. 1126).Licensing Information
Sold for research purposes under agreement from GlaxoSmithKlineProduct Specifications
Molecular Weight
492.46
Formula
C24H19F3N8O
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-Cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine
CAS Number
911110-38-8
PubChem ID
11853799
InChI Key
ZQFBVJBAWLZLOM-UHFFFAOYSA-N
SMILES
N=C(NC#N)NCCNC1=NC(C4=C(C)C=C(F)C=C4)=C(C=CC(N2C3=C(F)C=CC=C3F)=O)C2=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.25 | 100 |
Preparing Stock Solutions
for SB 706504
The following data is based on the product molecular weight 492.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.03 mL | 10.15 mL | 20.31 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.03 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for SB 706504
For research use only
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