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5 results for "Inward Rectifier Potassium Channel Activators" in Products

Inward Rectifier Potassium Channel Activators Products

The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors (SUR).

Structurally, the pore-forming subunit of Kir channels is the α-subunit. It contains a single pore domain between two membrane spanning regions. Four α-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. Kir3.2 with Kir3.3.

Selective Kir3.1/3.2 (GIRK1/2) channel activator

Chemical Name: N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea
Purity: ≥98% (HPLC)
Selective Kir3.1/3.2 (GIRK1/2) channel activator

Kir6 channel (KATP) opener

Chemical Name: 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide
Purity: ≥98% (HPLC)
Kir6 channel (KATP) opener

Selective activator of SUR1 Kir6.2 channels

Chemical Name: 7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Purity: ≥98% (HPLC)
Selective activator of SUR1 Kir6.2 channels

Kir6 (KATP) channel opener; active enantiomer of Cromakalim

Alternate Names: BRL 38227
Chemical Name: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Purity: ≥98% (HPLC)
Kir6 (KATP) channel opener; active enantiomer of Cromakalim

Selective inhibitor of Kir6.1 KATP channels

Chemical Name: 1-[(4-Methyl-2-thiophen-2-yl-1,3-thiazol-5-yl)methyl]-3-thiophen-2-ylurea
Purity: ≥98% (HPLC)
Selective inhibitor of Kir6.1 KATP channels
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