Levcromakalim is an active enantiomer of the prototypical K_ir6 (K_ATP) channel opener Cromakalim. Hypotensive and airways relaxant. IC₅₀ = 490 nM in guinea pig trachea.

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Product Specifications

Molecular Weight

286.33

Formula

C₁₆H₁₈N₂O₃

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile

CAS Number

94535-50-9

PubChem ID

93504

InChI Key

TVZCRIROJQEVOT-CABCVRRESA-N

SMILES

O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.86	10

Preparing Stock Solutions for Levcromakalim

The following data is based on the product molecular weight 286.33

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	34.92 mL	174.62 mL	349.25 mL
0.5 mM	6.98 mL	34.92 mL	69.85 mL
1 mM	3.49 mL	17.46 mL	34.92 mL
5 mM	0.70 mL	3.49 mL	6.98 mL

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Background References

References are publications that support the biological activity of the product.

Noack Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 1992 PMID: 1467843
Taylor The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways. J.Pharmacol.Exp.Ther. 1992 PMID: 1578358
Buckle Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols. J.Med.Chem. 1991 PMID: 2002472

Levcromakalim

Tocris Bioscience, part of Bio-Techne | Catalog # 1378

Key Product Details

Description

Alternative Names

View all Inward Rectifier Potassium Channel Activators »

Product Description