Levcromakalim

Name: Levcromakalim
Brand: Tocris Bioscience
SKU: 1378
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1378

Citations (3)

(1)

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Key Product Details

Description:	K_ir6 (K_ATP) channel opener; active enantiomer of Cromakalim
Alternative Names:	BRL 38227
Chemical Name:	(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
Purity:	≥99% (HPLC)
Molecular Weight:	286.33

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Biological Activity for Levcromakalim

Levcromakalim is an active enantiomer of the prototypical K_ir6 (K_ATP) channel opener Cromakalim. Hypotensive and airways relaxant. IC₅₀ = 490 nM in guinea pig trachea.

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Sold under license

Technical Data for Levcromakalim

M. Wt	286.33
Formula	C₁₆H₁₈N₂O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	94535-50-9
PubChem ID	93504
InChi Key	TVZCRIROJQEVOT-CABCVRRESA-N
Smiles	O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Levcromakalim

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.86	10

Preparing Stock Solutions for Levcromakalim

The following data is based on the product molecular weight 286.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	34.92 mL	174.62 mL	349.25 mL
0.5 mM	6.98 mL	34.92 mL	69.85 mL
1 mM	3.49 mL	17.46 mL	34.92 mL
5 mM	0.70 mL	3.49 mL	6.98 mL

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References for Levcromakalim

References are publications that support the biological activity of the product.

Noack Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 1992 PMID: 1467843
Taylor The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways. J.Pharmacol.Exp.Ther. 1992 PMID: 1578358
Buckle Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols. J.Med.Chem. 1991 PMID: 2002472

Citations for Levcromakalim (3)

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Citations are publications that use Bio-Techne products. Selected citations for Levcromakalim include:

Fransen et al. (2015) Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments. Lab Chip. 10:e0121634
PMID: 25803863
Garland et al. (2015) TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery. Br J Pharmacol. 172:1114
PMID: 25323322
Fike et al. (2013) Reactive oxygen species scavengers improve voltage-gated K(+) channel function in pulmonary arteries of newborn pigs with progressive hypoxia-induced pulmonary hypertension. Pulm Circ. 3:551
PMID: 24618540

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Levcromakalim was used on BK channel opening properties compared to cromakalim

Name: Anonymous

Species: Human

Assay Type: In Vitro

Levcromakalim was used on our lab to understand its BK channel opening properties compared to cromakalim. Results were reproducible.

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