5 results for "Inward Rectifier Potassium Channel Activators" in Products
Inward Rectifier Potassium Channel Activators Products
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors (SUR).
Structurally, the pore-forming subunit of Kir channels is the α-subunit. It contains a single pore domain between two membrane spanning regions. Four α-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. Kir3.2 with Kir3.3.
Selective Kir3.1/3.2 (GIRK1/2) channel activator
| Chemical Name: | N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea |
| Purity: | ≥98% (HPLC) |
Kir6 channel (KATP) opener
| Chemical Name: | 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide |
| Purity: | ≥98% (HPLC) |
Selective activator of SUR1 Kir6.2 channels
| Chemical Name: | 7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione |
| Purity: | ≥98% (HPLC) |
Kir6 (KATP) channel opener; active enantiomer of Cromakalim
| Alternate Names: | BRL 38227 |
| Chemical Name: | (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of Kir6.1 KATP channels
| Chemical Name: | 1-[(4-Methyl-2-thiophen-2-yl-1,3-thiazol-5-yl)methyl]-3-thiophen-2-ylurea |
| Purity: | ≥98% (HPLC) |
