Minoxidil

Name: Minoxidil
Brand: tocris
SKU: 0583
Rating: 5 (1 reviews)

Catalog # 0583

Citations (1)

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Bio-Techne Ltd.

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tel: 441235529449

info.emea@bio-techne.com

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Key Product Details

Description:	K_ir6 channel (K_ATP) opener
Chemical Name:	6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide
Purity:	≥99% (HPLC)
Molecular Weight:	209.25

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Biological Activity

Antihypertensive. Antialopecia agent. K_ir6 channel (K_ATP) activator.

Compound Libraries

Minoxidil is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	209.25
Formula	C₉H₁₅N₅O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	38304-91-5
PubChem ID	4201
InChi Key	ZIMGGGWCDYVHOY-UHFFFAOYSA-N
Smiles	NC1=CC(=NC(N)=[N+]1[O-])N1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	5.23	25
	DMSO	5.23	25 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 209.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	19.12 mL	95.58 mL	191.16 mL
1.25 mM	3.82 mL	19.12 mL	38.23 mL
2.5 mM	1.91 mL	9.56 mL	19.12 mL
12.5 mM	0.38 mL	1.91 mL	3.82 mL

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References

References are publications that support the biological activity of the product.

Lachgar Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells. Br.J.Dermatol. 1998 PMID: 9580790
Meisheri Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil. Biochem.Pharmacol. 1993 PMID: 8435087
Tsoporis Effects of the arterial vasodilator minoxidil on cardiovascular structure and sympathetic activity in spontaneously hypertensive rats. J.Hypertens. 1993 PMID: 8133016
Merck Index

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Minoxidil include:

Sun et al. (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep. 4:4934
PMID: 24816792

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Minoxidil used to study BK channel opening

Name: Sadequl Islam

Species: Human

Assay Type: In Vitro

Minoxidil was used based on its history as a potent potassium channel opener. It was used to study BK channel opening.

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Product Datasheets

COA

Certificate of Analysis

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Minoxidil

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References

Citations (1)

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Minoxidil used to study BK channel opening

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