ML 297
Tocris Bioscience, part of Bio-Techne | Catalog # 5380
Selective Kir3.1/3.2 (GIRK1/2) channel activator
Key Product Details
Description
Selective Kir3.1/3.2 (GIRK1/2) channel activator
Product Description
ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). Exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters. Prevents PTZ-induced epileptic seizures in mice. Brain penetrant.Licensing Information
Sold under license from Vanderbilt UniversityProduct Specifications
Molecular Weight
328.32
Formula
C17H14F2N4O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea
CAS Number
1443246-62-5
PubChem ID
56642816
InChI Key
IEKSMUSSYJUQMY-UHFFFAOYSA-N
SMILES
O=C(NC2=CC(C)=NN2C3=CC=CC=C3)NC1=CC(F)=C(F)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.83 | 100 | |
| Ethanol | 16.42 | 50 |
Preparing Stock Solutions
for ML 297
The following data is based on the product molecular weight 328.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.05 mL | 15.23 mL | 30.46 mL |
| 5 mM | 0.61 mL | 3.05 mL | 6.09 mL |
| 10 mM | 0.30 mL | 1.52 mL | 3.05 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wen Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg.Med.Chem.Lett. 2013 PMID: 23838260
- Kaufmann ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem.Neurosci. 2013 PMID: 23730969
Product Specific Notices for ML 297
For research use only
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