VU 0071063
Tocris Bioscience, part of Bio-Techne | Catalog # 7057
Selective activator of SUR1 Kir6.2 channels
Key Product Details
Description
Selective activator of SUR1 Kir6.2 channels
Product Description
VU 0071063 is a selective activator of SUR1 Kir6.2 channels and pancreatic β-cell KATP channels (EC50 = 7 μM and 0.3-10.3 μM, respectively). VU 0071063 inhibits insulin secretion in pancreatic β-cells by inducing hyperpolarization of β-cell membranes and reduces voltage-dependent calcium channel activation and Ca2+ influx. VU 0071063 is active in vivo and brain penetrant.Product Specifications
Molecular Weight
326.40
Formula
C18H22N4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
CAS Number
333415-38-6
PubChem ID
590142
InChI Key
ZFZAIHKQJBMYLO-UHFFFAOYSA-N
SMILES
CC(C)(C1=CC=C(CN2C=NC3=C2C(N(C)C(N3C)=O)=O)C=C1)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 1.63 | 5 |
Preparing Stock Solutions
for VU 0071063
The following data is based on the product molecular weight 326.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 61.27 mL | 306.37 mL | 612.75 mL |
| 0.25 mM | 12.25 mL | 61.27 mL | 122.55 mL |
| 0.5 mM | 6.13 mL | 30.64 mL | 61.27 mL |
| 2.5 mM | 1.23 mL | 6.13 mL | 12.25 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kharade Structure-activity relationships, pharmacokinetics, and pharmacodynamics of the Kir6.2/SUR1-specific channel opener VU0071063. J.Pharmacol.Exp.Ther. 2019 PMID: 31201216
- Raphemot Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol.Pharmacol. 2014 PMID: 24646456
Product Specific Notices for VU 0071063
For research use only
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