VU 0542270
Tocris Bioscience, part of Bio-Techne | Catalog # 8151
Selective inhibitor of Kir6.1 KATP channels
Key Product Details
Description
Selective inhibitor of Kir6.1 KATP channels
Product Description
VU 0542270 is a selective inhibitor of Kir6.1/SUR2B KATP channels (IC50 = 104 nM). Shows no activity at other Kir channel types at up to 30 μM. Dose-dependently induces constriction of ductus arteriosus vessels.Product Specifications
Molecular Weight
335.46
Formula
C14H13N3OS3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-[(4-Methyl-2-thiophen-2-yl-1,3-thiazol-5-yl)methyl]-3-thiophen-2-ylurea
CAS Number
1396814-79-1
PubChem ID
71795439
InChI Key
HMFDAWDOVRPGGW-UHFFFAOYSA-N
SMILES
O=C(NCC1=C(C)N=C(C2=CC=CS2)S1)NC3=CC=CS3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.55 | 100 |
Preparing Stock Solutions
for VU 0542270
The following data is based on the product molecular weight 335.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.98 mL | 14.90 mL | 29.81 mL |
| 5 mM | 0.60 mL | 2.98 mL | 5.96 mL |
| 10 mM | 0.30 mL | 1.49 mL | 2.98 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Li Discovery and characterization of VU0542270, the first selective inhibitor of vascular Kir6.1/SUR2B KATP channels. Mol.Pharmacol. 2024 PMID: 38302135
Product Specific Notices for VU 0542270
For research use only
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