IGF-I R/IGF1R Products
IGF-I R/IGF1R (Insulin-like Growth Factor I Receptor), also known as CD221, is a ubiquitously expressed heterotetrameric transmembrane glycoprotein consisting of two alpha and two beta subunits. It binds IGF-1 with high affinity, IGF2 with lower affinity, and Insulin with lowest affinity. IGF1R/Insulin R hybrids respond primarily to IGF-1 and may downregulate cellular responses to Insulin. IGF signaling is also modulated by IGF binding proteins and the scavenger receptor, IGF-II R/IGF2R. Mice lacking IGF1R show intrauterine growth deficiency and die at birth due to respiratory failure, and IGF1R mutations in humans can retarded pre- and postnatal growth. IGF-1 and its receptor are particularly important for neurogenesis, with deficiency producing microcephaly and learning disorders. IGF1R expression on human embryonic stem cells is important for their survival and clonogenicity.
Products:
596 results for "IGF-I R/IGF1R" in Products
596 results for "IGF-I R/IGF1R" in Products
IGF-I R/IGF1R Products
IGF-I R/IGF1R (Insulin-like Growth Factor I Receptor), also known as CD221, is a ubiquitously expressed heterotetrameric transmembrane glycoprotein consisting of two alpha and two beta subunits. It binds IGF-1 with high affinity, IGF2 with lower affinity, and Insulin with lowest affinity. IGF1R/Insulin R hybrids respond primarily to IGF-1 and may downregulate cellular responses to Insulin. IGF signaling is also modulated by IGF binding proteins and the scavenger receptor, IGF-II R/IGF2R. Mice lacking IGF1R show intrauterine growth deficiency and die at birth due to respiratory failure, and IGF1R mutations in humans can retarded pre- and postnatal growth. IGF-1 and its receptor are particularly important for neurogenesis, with deficiency producing microcephaly and learning disorders. IGF1R expression on human embryonic stem cells is important for their survival and clonogenicity.
Products:
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #33255 |
| Applications: | WB, Flow, IHC, ICC, Neut |
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC, ICC, Neut |
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
| Applications: | IHC, ICC/IF, Flow, Func, MA |
![Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948]](https://resources.bio-techne.com/images/products/IGF-I-R-IGF1R-Antibody-IGF1R-4667-Immunohistochemistry-Paraffin-NBP3-13948-img0003.jpg "Immunohistochemistry-Paraffin: IGF-I R/IGF1R Antibody (IGF1R/4667) [NBP3-13948]")
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
| Applications: | ICC/IF, Flow, MA |
![Protein Array: IGF-I R/IGF1R Antibody (IGF1R/4667) - Azide and BSA Free [NBP3-14094]](https://resources.bio-techne.com/images/products/IGF-I-R-IGF1R-Antibody-IGF1R-4667-Azide-and-BSA-Free-Protein-Array-NBP3-14094-img0001.jpg "Protein Array: IGF-I R/IGF1R Antibody (IGF1R/4667) - Azide and BSA Free [NBP3-14094]")
| Source: | NS0 |
| Accession #: | P08069 |
| Applications: | Bind |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #3G5C1 |
| Applications: | IHC, WB, ELISA |
![Western Blot: IGF-I R/IGF1R Antibody (3G5C1)BSA Free [NB110-87052]](https://resources.bio-techne.com/images/products/IGF-I-R-Antibody-3G5C1-Western-Blot-NB110-87052-img0021.jpg "Western Blot: IGF-I R/IGF1R Antibody (3G5C1)BSA Free [NB110-87052]")
| Reactivity: | Human, Mouse, Rat, Primate, Equine |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: IGF-I R/IGF1R AntibodyBSA Free [NBP1-77680]](https://resources.bio-techne.com/images/products/IGF-I-R-Antibody-Western-Blot-NBP1-77680-img0009.jpg "Western Blot: IGF-I R/IGF1R AntibodyBSA Free [NBP1-77680]")
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
| Applications: | ICC/IF, Flow, MA |
| Source: | NS0 |
| Accession #: | P08069 |
| Applications: | Bind |
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human |
| Details: | Mouse IgG2c Kappa Monoclonal Clone #IGF1R/4667 |
| Applications: | ICC/IF, Flow, MA |
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Simple Western |
![Western Blot: IGF-I R/IGF1R AntibodyBSA Free [NBP1-77679]](https://resources.bio-techne.com/images/products/IGF-I-R-Antibody-Western-Blot-NBP1-77679-img0009.jpg "Western Blot: IGF-I R/IGF1R AntibodyBSA Free [NBP1-77679]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #33255 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Assay Range: | 250 - 16,000 pg/mL |
| Applications: | ELISA |
| Source: | CHO |
| Accession #: | Q60751 |
| Applications: | BA |
| Source: | HEK293 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #33255 |
| Applications: | Flow |
