PQ 401
Tocris Bioscience, part of Bio-Techne | Catalog # 2768
IGF1R inhibitor
Key Product Details
Description
IGF1R inhibitor
Product Description
PQ 401 is an insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC50 value of 12 μM. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo.Product Specifications
Molecular Weight
341.79
Formula
C18H16ClN3O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea
CAS Number
196868-63-0
PubChem ID
9549305
InChI Key
YBLWOZUPHDKFOT-UHFFFAOYSA-N
SMILES
O=C(NC3=C(OC)C=CC(Cl)=C3)NC2=CC(C)=NC1=CC=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.09 | 50 | |
| Ethanol | 8.54 | 25 |
Preparing Stock Solutions
for PQ 401
The following data is based on the product molecular weight 341.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.85 mL | 29.26 mL | 58.52 mL |
| 2.5 mM | 1.17 mL | 5.85 mL | 11.70 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.85 mL |
| 25 mM | 0.12 mL | 0.59 mL | 1.17 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gable Diarylureas are small-molecule inhibitors of Ins-like growth factor I receptor signaling and breast cancer cell growth. Mol.Cancer 2006 PMID: 16648580
- Anderson Parallel synthesis of diarylureas and their evaluation as inhibitors of Ins-like growth factor receptor. J.Comb.Chem. 2006 PMID: 16961415
Product Specific Notices for PQ 401
For research use only
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