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IGF-I R/IGF1R Products

IGF-I R/IGF1R (Insulin-like Growth Factor I Receptor), also known as CD221, is a ubiquitously expressed heterotetrameric transmembrane glycoprotein consisting of two alpha and two beta subunits. It binds IGF-1 with high affinity, IGF2 with lower affinity, and Insulin with lowest affinity. IGF1R/Insulin R hybrids respond primarily to IGF-1 and may downregulate cellular responses to Insulin. IGF signaling is also modulated by IGF binding proteins and the scavenger receptor, IGF-II R/IGF2R. Mice lacking IGF1R show intrauterine growth deficiency and die at birth due to respiratory failure, and IGF1R mutations in humans can retarded pre- and postnatal growth. IGF-1 and its receptor are particularly important for neurogenesis, with deficiency producing microcephaly and learning disorders. IGF1R expression on human embryonic stem cells is important for their survival and clonogenicity.

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206 results for "IGF-I R/IGF1R" in Products

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IGF-I R/IGF1R Products

IGF-I R/IGF1R (Insulin-like Growth Factor I Receptor), also known as CD221, is a ubiquitously expressed heterotetrameric transmembrane glycoprotein consisting of two alpha and two beta subunits. It binds IGF-1 with high affinity, IGF2 with lower affinity, and Insulin with lowest affinity. IGF1R/Insulin R hybrids respond primarily to IGF-1 and may downregulate cellular responses to Insulin. IGF signaling is also modulated by IGF binding proteins and the scavenger receptor, IGF-II R/IGF2R. Mice lacking IGF1R show intrauterine growth deficiency and die at birth due to respiratory failure, and IGF1R mutations in humans can retarded pre- and postnatal growth. IGF-1 and its receptor are particularly important for neurogenesis, with deficiency producing microcephaly and learning disorders. IGF1R expression on human embryonic stem cells is important for their survival and clonogenicity.

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206 results for "IGF-I R/IGF1R" in Products

WB, Flow, IHC, ICC, Neut
WB, IHC, ICC, Neut
Flow, Func, ICC/IF, IHC, MA

Analyzed by SEC-MALS

IHC, WB, ICC/IF, Simple Western
WB
Catalog #: FAB391T
Flow
ICC/IF, IHC, WB

Recombinant Monoclonal Antibody

Flow
Catalog #: FAB391N
Flow
Catalog #: FAB391V
Flow
Catalog #: FAB391G
Flow
Catalog #: FAB391R
Flow
Catalog #: FAB391U
Flow
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