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12 results for "Histone Deacetylase 3/HDAC3 Small Molecules and Peptides" in Products

Histone Deacetylase 3/HDAC3 Small Molecules and Peptides

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone cetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone acetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Histone deacetylase inhibitor

Alternate Names:
VPA,Sodium Valproate
Chemical Name:
Sodium 2-propylpentanoate
Histone deacetylase inhibitor

Potent histone deacetylase inhibitor

Chemical Name:
(2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Purity:
≥95%
Potent histone deacetylase inhibitor

Class I and II HDAC inhibitor

Alternate Names:
Vorinostat
Chemical Name:
N-Hydroxy-N'-phenyloctanediamide
Purity:
≥98%
Class I and II HDAC inhibitor

Histone deacetylase inhibitor

Alternate Names:
4-PB,Sodium phenylbutyrate
Chemical Name:
4-Phenylbutyric acid, sodium salt
Purity:
≥98%
Histone deacetylase inhibitor

HDAC (Class I) inhibitor

Alternate Names:
entinostat,SNDX 275
Chemical Name:
(Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate
Purity:
≥98%
HDAC (Class I) inhibitor

Potent class I and IIb HDAC inhibitor

Chemical Name:
5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide
Purity:
≥98%
Potent class I and IIb HDAC inhibitor

Potent and selective HDAC3 inhibitor

Chemical Name:
(2E)-N-(2-Amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
Purity:
≥98%
Potent and selective HDAC3 inhibitor

Potent and selective HDAC3 inhibitor

Chemical Name:
(2E)-N-(2-Amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
Purity:
≥98%
Potent and selective HDAC3 inhibitor

Selective class I HDAC Degrader (PROTAC®)

Chemical Name:
(2S,4R)-1-((S)-2-(2-((9-(2-((4-((2-Aminophenyl)carbamoyl)phenyl)amino)-2-oxoethoxy)nonyl)oxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:
≥97%
Selective class I HDAC Degrader (PROTAC®)

Negative control for JPS036 (Cat. No. 8085).

Chemical Name:
(2S,4S)-1-((S)-2-(2-((9-(2-((4-((2-Aminophenyl)carbamoyl)phenyl)amino)-2-oxoethoxy)nonyl)oxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:
≥97%
Negative control for JPS036 (Cat. No. 8085).

Selective HDAC3 Degrader (PROTAC®)

Chemical Name:
(2S,4R)-N-[2-[[12-[[4-[(2-Aminophenyl)carbamoyl]phenyl]amino]-12-oxododecyl]oxy]-4-(4-methylthiazol-5-yl)benzyl]-1-[(S)-2-(1-fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide
Purity:
≥98%
Selective HDAC3 Degrader (PROTAC®)

Selective HDAC3 inhibitor; also myelination inducer

Chemical Name:
N-(2-Aminophenyl)-5-[(phenylmethyl)amino]-2-pyrazinecarboxamide dihydrochloride
Purity:
≥98%
Selective HDAC3 inhibitor; also myelination inducer
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