JPS036
Tocris Bioscience, part of Bio-Techne | Catalog # 8085
Selective HDAC3 Degrader (PROTAC®)
Key Product Details
Description
Selective HDAC3 Degrader (PROTAC®)
Product Description
JPS036 is a selective HDAC3 Degrader (PROTAC®) (DC50 = 440 nM; Dmax = 77 %). JPS036 comprises a benzamide-based compound joined by a linker to a Von Hippel Lindau (VHL) E3 ligase ligand.Negative control JPS016NC also available.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from the University of LeicesterProduct Specifications
Molecular Weight
940.19
Formula
C51H66FN7O7S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,4R)-N-[2-[[12-[[4-[(2-Aminophenyl)carbamoyl]phenyl]amino]-12-oxododecyl]oxy]-4-(4-methylthiazol-5-yl)benzyl]-1-[(S)-2-(1-fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide
CAS Number
2669785-85-5
PubChem ID
156808378
InChI Key
NAADBQUVFJWCFU-XVYMMXEDSA-N
SMILES
O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=C(C=C(C4=C(N=CS4)C)C=C3)OCCCCCCCCCCCC(NC5=CC=C(C=C5)C(NC6=C(C=CC=C6)N)=O)=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.8 | 20 with gentle warming |
Preparing Stock Solutions
for JPS036
The following data is based on the product molecular weight 940.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 5.32 mL | 26.59 mL | 53.18 mL |
| 1 mM | 1.06 mL | 5.32 mL | 10.64 mL |
| 2 mM | 0.53 mL | 2.66 mL | 5.32 mL |
| 10 mM | 0.11 mL | 0.53 mL | 1.06 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Smalley Optimization of class I histone deacetylase PROTACs reveals that HDAC1/2 degradation is critical to induce apoptosis and cell arrest in cancer cells. J.Med.Chem. 2022 PMID: 35293758
Product Specific Notices for JPS036
For research use only
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