JPS036

Name: JPS036
Brand: Tocris Bioscience
SKU: 8085

Tocris Bioscience, part of Bio-Techne | Catalog # 8085

COA / SDS

Selective HDAC3 Degrader (PROTAC®)

Key Product Details

Description:	Selective HDAC3 Degrader (PROTAC^®)
Chemical Name:	(2S,4R)-N-[2-[[12-[[4-[(2-Aminophenyl)carbamoyl]phenyl]amino]-12-oxododecyl]oxy]-4-(4-methylthiazol-5-yl)benzyl]-1-[(S)-2-(1-fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	940.19

View Full Technical Details for JPS036

Technical Data
Citations

Biological Activity for JPS036

JPS036 is a selective HDAC3 Degrader (PROTAC^®) (DC₅₀ = 440 nM; Dmax = 77 %). JPS036 comprises a benzamide-based compound joined by a linker to a Von Hippel Lindau (VHL) E3 ligase ligand.

Negative control JPS016NC also available.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from the University of Leicester

Technical Data for JPS036

M. Wt	940.19
Formula	C₅₁H₆₆FN₇O₇S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2669785-85-5
PubChem ID	156808378
InChi Key	NAADBQUVFJWCFU-XVYMMXEDSA-N
Smiles	O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=C(C=C(C4=C(N=CS4)C)C=C3)OCCCCCCCCCCCC(NC5=CC=C(C=C5)C(NC6=C(C=CC=C6)N)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JPS036

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.8	20 with gentle warming

Preparing Stock Solutions for JPS036

The following data is based on the product molecular weight 940.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	5.32 mL	26.59 mL	53.18 mL
1 mM	1.06 mL	5.32 mL	10.64 mL
2 mM	0.53 mL	2.66 mL	5.32 mL
10 mM	0.11 mL	0.53 mL	1.06 mL

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References for JPS036

References are publications that support the biological activity of the product.

Smalley Optimization of class I histone deacetylase PROTACs reveals that HDAC1/2 degradation is critical to induce apoptosis and cell arrest in cancer cells. J.Med.Chem. 2022 PMID: 35293758