BRD 73954
Tocris Bioscience, part of Bio-Techne | Catalog # 6284
Dual histone deacetylase (HDAC) 6/8 inhibitor
Key Product Details
Description
Dual histone deacetylase (HDAC) 6/8 inhibitor
Product Description
BRD 73954 is a dual histone deacetylase (HDAC) 6/8 inhibitor. IC50 values are 0.036 μM, 0.12 μM, 9 μM, >33 μM, for HDAC6, HDAC8, HDAC2 and HDAC4, respectively.Product Specifications
Molecular Weight
284.31
Formula
C16H16N2O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
CAS Number
1440209-96-0
PubChem ID
71680913
InChI Key
FIHKWEQJEDRIFS-UHFFFAOYSA-N
SMILES
ONC(C1=CC=CC(C(NCCC2=CC=CC=C2)=O)=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.43 | 100 | |
| Ethanol | 5.69 | 20 with gentle warming |
Preparing Stock Solutions
for BRD 73954
The following data is based on the product molecular weight 284.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.52 mL | 17.59 mL | 35.17 mL |
| 5 mM | 0.70 mL | 3.52 mL | 7.03 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Olson Discovery of the first histone deacetylase 6/8 dual inhibitors. J.Med.Chem. 2013 PMID: 23672185
Product Specific Notices for BRD 73954
For research use only
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