MS 275

Name: MS 275
Brand: Tocris Bioscience
SKU: 6208
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 6208

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Key Product Details

Description:	HDAC (Class I) inhibitor
Alternative Names:	entinostat, SNDX 275
Chemical Name:	(Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate
Purity:	≥99% (HPLC)
Molecular Weight:	376.41

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Biological Activity for MS 275

MS 275 is a class I HDAC inhibitor (IC₅₀ values are 0.18, 0.74, 44.9 and >100 μM for HDAC1, 3, 8 and 6, respectively). Exhibits antiproliferative effects and induces apoptosis in a range of tumor cell lines in vitro and in vivo. Increases estrogen receptor α- and aromatase expression in breast cancer cells. Inhibits PCB-induced neuronal cell death by preventing HDAC3 binding and histone deacetylation within the synapsin-1 promoter.

Compound Libraries for MS 275

MS 275 is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for MS 275

M. Wt	376.41
Formula	C₂₁H₂₀N₄O₃
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	209783-80-2
PubChem ID	4261
InChi Key	INVTYAOGFAGBOE-UHFFFAOYSA-N
Smiles	O=C(C1=CC=C(C=C1)CNC(OCC2=CN=CC=C2)=O)NC3=CC=CC=C3N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MS 275

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.64	100

Preparing Stock Solutions for MS 275

The following data is based on the product molecular weight 376.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.28 mL	26.57 mL
5 mM	0.53 mL	2.66 mL	5.31 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for MS 275

References are publications that support the biological activity of the product.

Formisano MS-275 inhibits aroclor 1254-induced SH-SY5Y neuronal cell toxicity by preventing the formation of the HDAC3/REST complex on the synapsin-1 promoter. J.Pharmacol.Exp.Ther. 2015 PMID: 25467131
Sabnis Functional activation of the estrogen receptor-α and aromatase by the HDAC inhibitor entinostat sensitizes ER-negative tumors to letr. Cancer Res. 2011 PMID: 21245100
Beckers Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int.J.Cancer 2007 PMID: 17455259
Saito A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. Proc.Natl.Acad.Sci. 1999 PMID: 10200307

Citations for MS 275 (1)

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Citations are publications that use Bio-Techne products. Selected citations for MS 275 include:

Kim (2018) Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition. Br J?Cancer. 118(10):1359
PMID: 29695769

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TGF beta high responder treated with 1.5 μM MS 275 (HDAC 3 inhibitor) for 48 h. Cell lysates were analysed by western blot.

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: C3-TAg tumour cell

TGF beta high responder treated with 1.5 μM MS 275 (HDAC 3 inhibitor) for 48 h. Cell lysates were analysed by western blot.

PMID: 29695769

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