RGFP 966

Tocris Bioscience, part of Bio-Techne | Catalog # 6728

Potent and selective HDAC3 inhibitor
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Key Product Details

Description

Potent and selective HDAC3 inhibitor

View all Class I Histone Deacetylases Inhibitors »

Product Description

RGFP 966 is a potent and selective HDAC3 inhibitor (IC50 = 80 nM); exhibits no effect on other HDAC (up to 15 μM). RGFP 966 reduces the frequency of striatal CAG repeat expansions in mouse models of Huntington's disease and reduces mHTT accumulation. RGFP 966 blocks the formation of reactive astrocytes and, in vivo, it is neuroprotective and enhances long-term object-location memory.

Product Specifications

Molecular Weight

362.40

Formula

C21H19FN4O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2E)-N-(2-Amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide

CAS Number

1357389-11-7

PubChem ID

56650312

InChI Key

BLVQHYHDYFTPDV-VCABWLAWSA-N

SMILES

NC1=C(C=CC(F)=C1)NC(/C=C/C2=CN(N=C2)C/C=C/C3=CC=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.24 100

Preparing Stock Solutions for RGFP 966

The following data is based on the product molecular weight 362.40

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.80 mL 27.59 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for RGFP 966

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RGFP 966

For research use only

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