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21 results for "GTPase Inhibitors Small Molecules and Peptides" in Products

GTPase Inhibitors: Small Molecules and Peptides

GTPases are a large group of enzymes that catalyze hydrolysis of the γ phosphate bond in guanine triphosphate (GTP) to form guanine diphosphate (GDP). Mg2+ is essential for catalytic activity. GTPases have essential roles in signal transduction, protein synthesis and translocation, control of cell growth and differentiation and vesicular transport regulation.

There are six main families of GTPases; heterotrimeric G protein GTPases (E.C. 3.6.5.1), small monomeric GTPases (E.C. 3.6.5.2), protein-synthesizing (translational) GTPases (E.C. 3.6.5.3), signal-recognition-particle GTPase (E.C. 3.6.5.4), dynamin GTPases (E.C. 3.6.5.5) and tubulin GTPases (E.C. 3.6.5.6).

Non-competitive dynamin inhibitor

Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
Purity: ≥98% (HPLC)
Non-competitive dynamin inhibitor

Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

Chemical Name: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
Purity: ≥98% (HPLC)
Selective dynamin inhibitor; attenuates mitochondrial division and apoptosis

Potent Rac family inhibitor

Chemical Name: 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride
Purity: ≥98% (HPLC)
Potent Rac family inhibitor

Selective inhibitor of Rac1-GEF interaction; antioncogenic

Chemical Name: N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
Purity: ≥98% (HPLC)
Selective inhibitor of Rac1-GEF interaction; antioncogenic

Potent farnesyl diphosphate (FPP) synthase inhibitor

Alternate Names: Zometa
Chemical Name: [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid
Purity: ≥98% (HPLC)
Potent farnesyl diphosphate (FPP) synthase inhibitor

Selective Cdc42 Rho family inhibitor

Alternate Names: CID 2950007
Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide
Purity: ≥98% (HPLC)
Selective Cdc42 Rho family inhibitor

Gα-protein inhibitor; potent inhibitor of Gq/11 signaling

Chemical Name: (R)-1-((3S,6S,9S,12S,18R,21S,22R)-21-acetamido-18-benzyl-3-((R)-1-methoxyethyl)-4,9,10,12,16,22-hexamethyl-15-methylene-2,5,8,11,14,17,20-heptaoxo-1,19-dioxa-4,7,10,13,16-pentaazacyclodocosan-6-yl)-2-methylpropyl (2S,3R)-2-acetamido-3-hydroxy-4-methylpentanoate
Purity: ≥95% (HPLC)
Gα-protein inhibitor; potent inhibitor of Gq/11 signaling

Rho inhibitor

Chemical Name: D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
Purity: ≥98% (HPLC)
Rho inhibitor

Rac inhibitor

Chemical Name: N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine
Purity: ≥98% (HPLC)
Rac inhibitor

Dynamin I inhibitor

Chemical Name: 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
Purity: ≥98% (HPLC)
Dynamin I inhibitor

DOCK2-Rac1 interaction inhibitor

Chemical Name: 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
Purity: ≥98% (HPLC)
DOCK2-Rac1 interaction inhibitor

Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis

Chemical Name: [4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)methanone
Purity: ≥98% (HPLC)
Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis

Epac inhibitor

Chemical Name: α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
Purity: ≥98% (HPLC)
Epac inhibitor

Selective ARF6 inhibitor

Chemical Name: 3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Purity: ≥98% (HPLC)
Selective ARF6 inhibitor

Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable

Purity: ≥95% (HPLC)
Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable

Geranylgeranyltransferase-I (GGTase-I) inhibitor

Chemical Name: (2R)-3,3,3-Trifluoro-2-methoxy-1-[(7R)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undec-3-yl]-2-phenyl-1-propanone hydrochloride
Purity: ≥98% (HPLC)
Geranylgeranyltransferase-I (GGTase-1) inhibitor

Dynamin inhibitor; analog of dynasore (Cat. No. 2897)

Alternate Names: Dyngo 4a
Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide
Purity: ≥98% (HPLC)
Dynamin inhibitor; analog of dynasore (Cat. No. 2897)

High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ

Chemical Name: 2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride
Purity: ≥98% (HPLC)
High affinity PDEδ-KRas interaction inhibitor; binds to PDEδ

Selective Epac2 inhibitor

Chemical Name: 2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole
Purity: ≥98% (HPLC)
Selective Epac2 inhibitor

Epac2 inhibitor

Chemical Name: 1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene
Purity: ≥98% (HPLC)
Epac2 inhibitor

Potent covalent inhibitor of the RAS domain of the PI3K/p110α interaction

Chemical Name: 5-((1R,2S,5S)-2-(2-Chloro-3-fluorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl)-N-((R,E)-4-(methylsulfonyl)but-3-en-2-yl)pyrazine-2-carboxamide
Purity: ≥98% (HPLC)
Potent covalent inhibitor of the RAS domain of the PI3K/p110α interaction
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