ML 141
Tocris Bioscience, part of Bio-Techne | Catalog # 4266
Selective Cdc42 Rho family inhibitor
Key Product Details
Description
Selective Cdc42 Rho family inhibitor
Alternative Names
CID 2950007
Product Description
ML 141 is an allosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.Product Specifications
Molecular Weight
407.49
Formula
C22H21N3O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide
CAS Number
71203-35-5
PubChem ID
2950007
InChI Key
QBNZBMVRFYREHK-UHFFFAOYSA-N
SMILES
COC(C=C4)=CC=C4C1CC(C3=CC=CC=C3)=NN1C2=CC=C(S(=O)(N)=O)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.75 | 100 |
Preparing Stock Solutions
for ML 141
The following data is based on the product molecular weight 407.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.27 mL | 24.54 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.91 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hong Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe. J.Biol.Chem. 2013 PMID: 23382385
- Surviladze A potent and selective inhibitor of Cdc42 GTPase. Probe Reports from the Molecular Libraries Program 2010 PMID: 21433396
Product Specific Notices for ML 141
For research use only
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