Dynole 34-2
Tocris Bioscience, part of Bio-Techne | Catalog # 4222
Dynamin I inhibitor
Product Description
Dynole 34-2 is a dynamin I inhibitor (IC50 = 1.3 μM). Inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM).Product Specifications
Molecular Weight
408.58
Formula
C25H36N4O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide
CAS Number
1128165-88-7
PubChem ID
44157463
InChI Key
MYIMRONQBLZJFI-DYTRJAOYSA-N
SMILES
CN(C)CCCN2C1=CC=CC=C1C(/C=C(C(NCCCCCCCC)=O)\C#N)=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.86 | 100 | |
| Ethanol | 20.43 | 50 |
Preparing Stock Solutions
for Dynole 34-2
The following data is based on the product molecular weight 408.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.24 mL | 24.48 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.90 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hill Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J.Med.Chem. 2010 PMID: 20426422
- Hill Inhibition of dynamin mediated endocytosis by the dynoles - synthesis and functional activity of a family of indoles. J.Med.Chem. 2009 PMID: 19459681
Product Specific Notices for Dynole 34-2
For research use only
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