ESI 09

Name: ESI 09
Brand: Tocris Bioscience
SKU: 4773

Tocris Bioscience a Bio-Techne Brand

Catalog # 4773

Citations (4)

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Key Product Details

Description:	Epac inhibitor
Chemical Name:	α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
Purity:	≥98% (HPLC)
Molecular Weight:	330.77

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Biological Activity for ESI 09

ESI 09 is an EPAC inhibitor. Inhibits EPAC-mediated insulin release from pancreatic β cells. Selective for EPAC over PKA. ESI 09 decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells in vitro.

Compound Libraries for ESI 09

ESI 09 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ESI 09

M. Wt	330.77
Formula	C₁₆H₁₅ClN₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	263707-16-0
PubChem ID	6077765
InChi Key	DXEATJQGQHDURZ-DEDYPNTBSA-N
Smiles	CC(C)(C)C1=CC(C(/C(C#N)=N/NC2=CC=CC(Cl)=C2)=O)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ESI 09

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.08	100
	ethanol	6.62	20

Preparing Stock Solutions for ESI 09

The following data is based on the product molecular weight 330.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.12 mL	30.23 mL
5 mM	0.60 mL	3.02 mL	6.05 mL
10 mM	0.30 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for ESI 09

References are publications that support the biological activity of the product.

Almahariq A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol.Pharmacol. 2013 PMID: 23066090

Citations for ESI 09 (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for ESI 09 include:

Perkins et al. (2018) Autocrine-paracrine prostaglandin E₂ signaling restricts TLR4 internalization and TRIF signaling. Nat.Immunol.. 19:1309
PMID: 30397349
Drelich et al. (2018) Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells. Viruses. 10
PMID: 30332733
Guichard et al. (2017) Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog. 13:e1006603
PMID: 28945820
Wang et al. (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation. EMBO Mol Med. 11:2057
PMID: 26649942

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