Hydroxy Dynasore
Tocris Bioscience, part of Bio-Techne | Catalog # 5364
Dynamin inhibitor; analog of dynasore (Cat. No. 2897)
Key Product Details
Description
Dynamin inhibitor; analog of dynasore (Cat. No. 2897)
Alternative Names
Dyngo 4a
Product Description
Hydroxy Dynasore is a dynamin inhibitor (IC50 values are 0.38 and 2.6 μM for dynamin 1 and 2 respectively). Inhibits dynamin-mediated endocytosis in multiple cell types and reduces synaptic vesicle endocytosis in vitro. Prevents botulinum A internalization in hippocampal neurons. Also protects against botulinum A-induced muscle paralysis in rats. Analog of Dynasore (Cat. No. 2897).Product Specifications
Molecular Weight
338.31
Formula
C18H14N2O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide
CAS Number
1256493-34-1
PubChem ID
72193863
InChI Key
ATUDAZGVGGVSOP-XFXZXTDPSA-N
SMILES
OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=C(O)C=C(O)C(O)=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.23 | 100 |
Preparing Stock Solutions
for Hydroxy Dynasore
The following data is based on the product molecular weight 338.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.78 mL | 29.56 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.91 mL |
| 10 mM | 0.30 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- McCluskey Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic 2013 PMID: 24025110
- Harper Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism. J.Biol.Chem. 2011 PMID: 21832053
Product Specific Notices for Hydroxy Dynasore
For research use only
Loading...
Loading...