17 results for "GSK-3 beta" in Products
GSK-3 beta Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.
Highly selective GSK-3 inhibitor; acts as Wnt activator
Inhibitor of protein synthesis
Potent, selective GSK-3 inhibitor
Potent, selective GSK-3 inhibitor
Potent GSK-3 inhibitor; also inhibits cdks
Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor
Highly potent and selective GSK-3 inhibitor
GSK-3β inhibitor; also inhibits cdks
Potent GSK-3β inhibitor
Selective GSK-3 inhibitor
Potent and selective GSK-3β inhibitor
Highly potent, selective GSK-3 inhibitor
Potent and selective cdk inhibitor; orally bioavailable
Selective non-ATP competitive inhibitor of GSK 3β
Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation
Notum inhibitor; activates Wnt signaling
Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation