TC-G 24

Name: TC-G 24
Brand: Tocris Bioscience
SKU: 4353

Tocris Bioscience, part of Bio-Techne | Catalog # 4353

Citations (9)

COA / SDS

Potent and selective GSK-3β inhibitor

Key Product Details

Description:	Potent and selective GSK-3β inhibitor
Chemical Name:	N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine
Purity:	≥98% (HPLC)
Molecular Weight:	330.73

View Full Technical Details for TC-G 24

Technical Data
Citations

Biological Activity for TC-G 24

TC-G 24 is a potent GSK-3β inhibitor (IC₅₀ = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.

Technical Data for TC-G 24

M. Wt	330.73
Formula	C₁₅H₁₁ClN₄O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1257256-44-2
PubChem ID	49857866
InChi Key	JYCNWQGNEJYDQS-UHFFFAOYSA-N
Smiles	CC(C=C3)=C(Cl)C=C3NC1=NN=C(C2=CC=C([N+]([O-])=O)C=C2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-G 24

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.31	10 with gentle warming

Preparing Stock Solutions for TC-G 24

The following data is based on the product molecular weight 330.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.24 mL	151.18 mL	302.36 mL
0.5 mM	6.05 mL	30.24 mL	60.47 mL
1 mM	3.02 mL	15.12 mL	30.24 mL
5 mM	0.60 mL	3.02 mL	6.05 mL

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References for TC-G 24

References are publications that support the biological activity of the product.

Khanfar Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J.Med.Chem. 2010 PMID: 21082766