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CD117/c-kit Products
CD117, also known as c-kit and SCF R, is the cellular receptor for Stem Cell Factor (SCF), also named c-kit ligand, mast cell growth factor, and steel factor. This receptor-ligand system plays essential roles in germ cell development, melanogenesis, hematopoiesis, and oncogenesis. CD117 is expressed on lymphoid, myeloid, erythroid, and megakaryocyte progenitors, NK cells, germ cells, melanocytes, glial cells, vascular smooth muscle cells, placenta, and epithelial cells. Altered levels and mutations in CD117 are associated with several types of cancer including lung, breast, gastrointestinal stromal, and germ cell tumors.
47 results for "CD117/c-kit" in Products
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CD117/c-kit Products
CD117, also known as c-kit and SCF R, is the cellular receptor for Stem Cell Factor (SCF), also named c-kit ligand, mast cell growth factor, and steel factor. This receptor-ligand system plays essential roles in germ cell development, melanogenesis, hematopoiesis, and oncogenesis. CD117 is expressed on lymphoid, myeloid, erythroid, and megakaryocyte progenitors, NK cells, germ cells, melanocytes, glial cells, vascular smooth muscle cells, placenta, and epithelial cells. Altered levels and mutations in CD117 are associated with several types of cancer including lung, breast, gastrointestinal stromal, and germ cell tumors.
47 results for "CD117/c-kit" in Products
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #47233 |
| Applications : | Flow Cytometry |
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Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Simple Western, Western Blot |
Contains 4 membranes-each spotted in duplicate with 49 different antibodies to ubiquitin target proteins
Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
| Alternate Names : | Semaxinib |
| Chemical Name : | 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one |
| Purity : | ≥99% (HPLC) |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Immunohistochemistry, Simple Western, Western Blot |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #47233 |
| Applications : | Block/Neutralize, CyTOF-ready, ELISA Capture, Flow Cytometry, Simple Western, Western Blot |
| Clonality : | Polyclonal |
| Host : | Rabbit IgG |
| Applications : | Immunohistochemistry, Simple Western, Western Blot |
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit
| Alternate Names : | Gleevec, CGP 57148B |
| Chemical Name : | 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate |
| Purity : | ≥98% (HPLC) |
| Source : | HEK293 |
| Accession # : | P10721.1 |
| Applications : | Bioactivity |
| Clonality : | Polyclonal |
| Host : | Rabbit IgG |
| Applications : | Immunohistochemistry, Western Blot |
c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation
| Chemical Name : | N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea |
| Purity : | ≥97% (HPLC) |
Potent and selective PDGFR family inhibitor
| Chemical Name : | N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide |
| Purity : | ≥99% (HPLC) |
| Source : | Sf 21 (baculovirus) |
| Accession # : | P10721 |
| Applications : | Bioactivity |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #47233 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #47233 |
| Applications : | Flow Cytometry |
| Applications : | ELISA |
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
| Chemical Name : | 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine |
| Purity : | ≥98% (HPLC) |
| Assay Range : | 31.2 - 2,000 pg/mL |
| Applications : | ELISA |
Potent VEGFR inhibitor; also aromatase inhibitor
| Alternate Names : | CGP 79787D, PTK787/ZK222584 |
| Chemical Name : | N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate |
| Purity : | ≥99% (HPLC) |
