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CD117/c-kit: Small Molecules and Peptides

CD117, also known as c-kit and SCF R, is the cellular receptor for Stem Cell Factor (SCF), also named c-kit ligand, mast cell growth factor, and steel factor. This receptor-ligand system plays essential roles in germ cell development, melanogenesis, hematopoiesis, and oncogenesis. CD117 is expressed on lymphoid, myeloid,  erythroid, and megakaryocyte progenitors, NK cells, germ cells, melanocytes, glial cells, vascular smooth muscle cells, placenta, and epithelial cells. Altered levels and mutations in CD117 are associated with several types of cancer including lung, breast, gastrointestinal stromal, and germ cell tumors.

7 results for "CD117/c-kit Small Molecules and Peptides" in Products

CD117/c-kit: Small Molecules and Peptides

CD117, also known as c-kit and SCF R, is the cellular receptor for Stem Cell Factor (SCF), also named c-kit ligand, mast cell growth factor, and steel factor. This receptor-ligand system plays essential roles in germ cell development, melanogenesis, hematopoiesis, and oncogenesis. CD117 is expressed on lymphoid, myeloid,  erythroid, and megakaryocyte progenitors, NK cells, germ cells, melanocytes, glial cells, vascular smooth muscle cells, placenta, and epithelial cells. Altered levels and mutations in CD117 are associated with several types of cancer including lung, breast, gastrointestinal stromal, and germ cell tumors.

7 results for "CD117/c-kit Small Molecules and Peptides" in Products

VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation

Potent VEGFR inhibitor; also aromatase inhibitor

Potent and selective PDGFR family inhibitor

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