Vatalanib succinate

Name: Vatalanib succinate
Brand: Tocris Bioscience
SKU: 5680

Tocris Bioscience, part of Bio-Techne | Catalog # 5680

Citations (3)

COA / SDS

Potent VEGFR inhibitor; also aromatase inhibitor

Key Product Details

Description:	Potent VEGFR inhibitor; also aromatase inhibitor
Alternative Names:	CGP 79787D,PTK787/ZK222584
Chemical Name:	N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate
Purity:	≥98% (HPLC)
Molecular Weight:	464.9

View Full Technical Details for Vatalanib succinate

Technical Data
Citations

Biological Activity for Vatalanib succinate

Vatalanib succinate is a potent VEGFR inhibitor (IC₅₀ values are 37 and 77 nM for VEGFR-2 and -1, respectively). Inhibits proliferation, migration and survival of HUVECs in vitro and inhibits growth, vascularization and metastasis of tumors expressing VEGFR in mouse models. Also inhibits PDGFR-β, c-Kit and c-Fms. Potent aromatase inhibitor (IC₅₀ = 50 nM). Orally available.

Technical Data for Vatalanib succinate

M. Wt	464.9
Formula	C₂₀H₁₅ClN₄.C₄H₆O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	212142-18-2
PubChem ID	151193
InChi Key	LLDWLPRYLVPDTG-UHFFFAOYSA-N
Smiles	ClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42.OC(CCC(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Vatalanib succinate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.49	100

Preparing Stock Solutions for Vatalanib succinate

The following data is based on the product molecular weight 464.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.76 mL	21.51 mL
5 mM	0.43 mL	2.15 mL	4.30 mL
10 mM	0.22 mL	1.08 mL	2.15 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for Vatalanib succinate

References are publications that support the biological activity of the product.

Wood PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000 PMID: 10786682
Bold New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis. J.Med.Chem. 2000 PMID: 10956229
Banerjee The vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 inhibits aromatase. Cancer Res. 2009 PMID: 19435899