BTK Products
Bruton tyrosine kinase (Btk) is a 75 kDa cytoplasmic protein tyrosine kinase that is widely expressed in hematopoietic cells. Btk is required for B cell receptor signaling and B cell development. Defects in Btk result in X-linked agammaglobulinemia which is characterized by a severely decreased level of circulating antibodies. Like other Tec family kinases, Btk contains a Pleckstrin homology domain, a Tec homology domain, an SH3 domain, an SH2 domain, and a protein kinase domain. Association of the Btk SH2 domain with the B cell linker protein (BLNK) is required for the activation of PLC? by Btk. The autophosphorylation of Tyr223 facilitates the interaction of Btk with activated Syk. Within the SH2 domain (aa 280 - 377), human Btk shares 99% aa sequence identity with mouse and rat Btk.
299 results for "BTK" in Products
299 results for "BTK" in Products
BTK Products
Bruton tyrosine kinase (Btk) is a 75 kDa cytoplasmic protein tyrosine kinase that is widely expressed in hematopoietic cells. Btk is required for B cell receptor signaling and B cell development. Defects in Btk result in X-linked agammaglobulinemia which is characterized by a severely decreased level of circulating antibodies. Like other Tec family kinases, Btk contains a Pleckstrin homology domain, a Tec homology domain, an SH3 domain, an SH2 domain, and a protein kinase domain. Association of the Btk SH2 domain with the B cell linker protein (BLNK) is required for the activation of PLC? by Btk. The autophosphorylation of Tyr223 facilitates the interaction of Btk with activated Syk. Within the SH2 domain (aa 280 - 377), human Btk shares 99% aa sequence identity with mouse and rat Btk.
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, Flow, Func |
![Western Blot: BTK [p Tyr223] AntibodyBSA Free [NBP1-78295]](https://resources.bio-techne.com/images/products/BTK-[p-Tyr223]-Antibody-Western-Blot-NBP1-78295-img0004.jpg "Western Blot: BTK [p Tyr223] AntibodyBSA Free [NBP1-78295]")
| Reactivity: | Human, Primate |
| Details: | Mouse IgG1 Monoclonal Clone #7F12H4 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: BTK Antibody (7F12H4)BSA Free [NB110-87047]](https://resources.bio-techne.com/images/products/BTK-Antibody-7F12H4-Western-Blot-NB110-87047-img0009.jpg "Western Blot: BTK Antibody (7F12H4)BSA Free [NB110-87047]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #566928 |
| Applications: | WB, Simple Western, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #797837 |
| Applications: | WB, Simple Western |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3A2 |
| Applications: | IHC, WB, ICC/IF, Flow |
![Western Blot: BTK Antibody (OTI3A2) [NBP2-02472]](https://resources.bio-techne.com/images/products/BTK-Antibody-3A2-Western-Blot-NBP2-02472-img0002.jpg "Western Blot: BTK Antibody (OTI3A2) [NBP2-02472]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #OTI3A2 |
| Applications: | IHC, WB, ICC/IF, Flow, CyTOF-ready |
![Western Blot: BTK Antibody (OTI3A2)Azide and BSA Free [NBP2-70291]](https://resources.bio-techne.com/images/products/BTK-Antibody-OTI3A2-Azide-and-BSA-Free-Western-Blot-NBP2-70291-img0001.jpg "Western Blot: BTK Antibody (OTI3A2)Azide and BSA Free [NBP2-70291]")
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #720101 |
| Applications: | WB, ICC |
| Reactivity: | Human, Primate |
| Details: | Mouse IgG1 Monoclonal Clone #7F12H4 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: BTK Antibody (7F12H4)Azide and BSA Free [NBP2-80605]](https://resources.bio-techne.com/images/products/BTK-Antibody-7F12H4-Azide-and-BSA-Free-Western-Blot-NBP2-80605-img0002.jpg "Western Blot: BTK Antibody (7F12H4)Azide and BSA Free [NBP2-80605]")
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #720101 |
| Applications: | WB, ICC |
| Reactivity: | Human, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Immunohistochemistry-Paraffin: BTK Antibody [NBP1-89207]](https://resources.bio-techne.com/images/products/BTK-Antibody-Immunohistochemistry-Paraffin-NBP1-89207-img0011.jpg "Immunohistochemistry-Paraffin: BTK Antibody [NBP1-89207]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #566928 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #720101 |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: BTK AntibodyBSA Free [NBP1-76596]](https://resources.bio-techne.com/images/products/BTK-Antibody-Western-Blot-NBP1-76596-img0003.jpg "Western Blot: BTK AntibodyBSA Free [NBP1-76596]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: BTK Antibody [NBP1-89206]](https://resources.bio-techne.com/images/products/BTK-Antibody-Western-Blot-NBP1-89206-img0010.jpg "Western Blot: BTK Antibody [NBP1-89206]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #566928 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #566928 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #566928 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #566928 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #566928 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #3005A |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #566928 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #566928 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #720101 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #720101 |
| Applications: | WB, ICC |