PCI 29732
Tocris Bioscience, part of Bio-Techne | Catalog # 5012
Potent BTK inhibitor
Key Product Details
Description
Potent BTK inhibitor
Product Description
PCI 29732 is a potent BTK inhibitor (IC50 = 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+ B cells.Product Specifications
Molecular Weight
371.44
Formula
C22H21N5O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS Number
330786-25-9
PubChem ID
22347110
InChI Key
GMJUPMONHWAZCP-UHFFFAOYSA-N
SMILES
NC1=C2C(N(C4CCCC4)N=C2C3=CC=C(OC5=CC=CC=C5)C=C3)=NC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.14 | 100 | |
| Ethanol | 18.57 | 50 |
Preparing Stock Solutions
for PCI 29732
The following data is based on the product molecular weight 371.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.69 mL | 13.46 mL | 26.92 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.38 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.69 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Krishnamurty Active site profiling reveals coupling between domains in SRC-family kinases. Nat.Chem.Biol. 2013 PMID: 23143416
- Honigberg The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc.Natl.Acad.Sci.U.S.A. 2010 PMID: 20615965
Product Specific Notices for PCI 29732
For research use only
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