Human BTK (NP_000052) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC1707
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: BTK
Bruton tyrosine kinase (Btk) is a 75 kDa cytoplasmic protein tyrosine kinase that is widely expressed in hematopoietic cells. Btk is required for B cell receptor signaling and B cell development. Defects in Btk result in X-linked agammaglobulinemia which is characterized by a severely decreased level of circulating antibodies. Like other Tec family kinases, Btk contains a Pleckstrin homology domain, a Tec homology domain, an SH3 domain, an SH2 domain, and a protein kinase domain. Association of the Btk SH2 domain with the B cell linker protein (BLNK) is required for the activation of PLC? by Btk. The autophosphorylation of Tyr223 facilitates the interaction of Btk with activated Syk. Within the SH2 domain (aa 280 - 377), human Btk shares 99% aa sequence identity with mouse and rat Btk.
Long Name
Bruton Agammaglobulinemia Tyrosine Kinase
Alternate Names
AGMX1, IMD1, PSCTK1, XLA
Entrez Gene IDs
695 (Human)
Gene Symbol
BTK
UniProt
Additional BTK Products
Product Documents for Human BTK (NP_000052) VersaClone cDNA
Product Specific Notices for Human BTK (NP_000052) VersaClone cDNA
For research use only
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