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Key Product Details
| Description: | Endogenous retinoic acid receptor agonist |
| Alternative Names: | Tretinoin, ATRA |
| Chemical Name: | 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E,-nonatetraenoic acid |
| Purity: | ≥99% (HPLC) |
| Molecular Weight: | 300.44 |
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Biological Activity
Endogenous agonist for retinoic acid receptors (IC50 = 14 nM for RARα, RARβ and RARγ receptors). Also promotes differentiation of mouse embryonic stem cells (ESCs) into adipocytes, neurons and glia in vitro. Proposed ligand of RORβ (Kd = 280 nM). Activates autophagy.
Motor neurons differentiated from hiPSCs using Retinoic Acid
Image shows IBJ6 human fibroblast induced pluripotent stem cells which have been differentiated into motor neurons. This was performed using a combination of LDN 193189 (100 nM) (Cat. No. 6053) and SB 431542 (Cat. No. 1614) followed by Retinoic acid and Purmorphamine (Cat. No. 4551) culture on Laminin for 18 days. Commitment to the motor neuron fate was assessed using the motor neuron marker anti-Human Islet-1 (red, R&D Systems®, Cat. No. AF1837) and the general neuronal marker, beta III tubulin (green, R&D Systems®, Cat. No. MAB1195). For visualization, the neurons were stained using Northernlights™ 557-conjugated Donkey anti-Goat Secondary Antibody (R&D Systems®, Cat. No. NL001) and Northernlights™ 493-conjugated Donkey anti-Mouse Secondary Antibody (R&D Systems®, Cat. No. NL009) and counterstained with DA
Citations (6)
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Citations are publications that use Bio-Techne products. Selected citations for Retinoic acid include:
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Li et al.
(2018)
Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells.
Stem Cell Reports.
11:998
PMID: 30269954 -
Bohnenpoll
(2017)
Retinoic acid signaling maintains epithelial and mesenchymal progenitors in the developing mouse ureter.
Sci Rep.
7(1):14803
PMID: 29093497 -
Jaako et al.
(2016)
Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro.
J Cell Sci.
129:3792
PMID: 27566163 -
Lewis et al.
(2015)
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
J Med Food.
11:189
PMID: 25622091 -
Davies et al.
(2012)
Evolution and functional characterisation of melanopsins in a deep-sea chimaera (elephant shark, Callorhinchus milii).
PLoS One.
7:e51276
PMID: 23251480 -
Han et al.
(2012)
Berberine promotes axonal regeneration in injured nerves of the peripheral nervous system.
Physiol Behav.
15:413
PMID: 22316297
There are no citations that match your criteria.
⚠ WARNING: This product can expose you to chemicals including All-trans retinoic acid, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
