Human/Mouse/Rat/Hamster ACE-2 Antibody
Order Information
Shipping Information
$35 to United States
Products in stock will be shipped in 1-3 business days unless specified.
Key Product Details
Species Reactivity: | Human, Mouse, Rat, Hamster |
Immunogen: |
Mouse myeloma cell line NS0-derived recombinant human ACE-2 Gln18-Ser740 Accession # Q9BYF1 |
Applications: | Block/Neutralize, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Simple Western, Western Blot |
Label: | Unconjugated |
Source: | Polyclonal Goat IgG |
Specificity: |
Detects human ACE-2 in direct ELISAs. Detects human, mouse, and rat ACE-2 in Western blots. Detects Hamster ACE-2 in immunohistochemistry. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human ACE is observed. |
Complete Your Research
Complete Your Experiment
Citations for Human/Mouse/Rat/Hamster ACE-2 Antibody (77)
Citations are publications that use Bio-Techne products. Selected citations for Human/Mouse/Rat/Hamster ACE-2 Antibody include:
-
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA DetectionJ Shi et al. (2021), Receptor-Binding Domain Proteins of SARS-CoV-2 Variants Elicited Robust Antibody Responses Cross-Reacting with Wild-Type and Mutant Viruses in Mice Vaccines, 9(12).
PMID: 34960131 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotEJ Sherman et al. (2021), ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes Scientific Reports, 11(1):15900.
PMID: 34354120 -
Species: Rat
Sample Types: Tissue Homogenates
EE Khoury et al. (2021), Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease Journal of Cellular and Molecular Medicine, 0(0).
PMID: 33660945 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryK Uemura et al. (2021), MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2 Scientific Reports, 11(1):5376.
PMID: 33686154 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotJ Baggen et al. (2021), Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2 Nature Genetics, 0(0).
PMID: 33686287 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryY Zhang et al. (2021), SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication Nature Communications, 12(1):1676.
PMID: 33723254 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryH Huerga Enc et al. (2021), Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients Stem Cell Reports, 16(3):428-436.
PMID: 33581053 -
Species: Human
Sample Types: Whole Tissue
Applications: IHCAZ Eriksen et al. (2021), SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium Cell Stem Cell, 0(0).
PMID: 34022129 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryF Onodi et al. (2021), SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4 bioRxiv : the preprint server for biology, 0(0).
PMID: 33442685 -
Species: Rat
Sample Types: Whole Tissue
Applications: IHCS Sugimoto et al. (2021), An organoid-based organ-repurposing approach to treat short bowel syndrome Nature, 0(0).
PMID: 33627870 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotM Puray-Chav et al. (2021), Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell Cell Reports, 0(0):109364.
PMID: 34214467 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotM Dittmar et al. (2021), Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2 Cell Reports, 35(1):108959.
PMID: 33811811 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotM Zhao et al. (2021), Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2 PloS Pathogens, 17(6):e1009683.
PMID: 34166473 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotCLC Almeida-da et al. (2021), Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells International Journal of Molecular Sciences, 22(14).
PMID: 34299289 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryX Wang et al. (2021), Deletion of ER-retention motif on SARS-CoV-2 spike protein reduces cell hybrid during cell-cell fusion Cell bioscience, 2021;11(1):114.
PMID: 34162440 -
Species: Human
Sample Types: Organoid
Applications: IHCL Wang et al. (2021), A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology Nature Medicine, 0(0).
PMID: 34244682 -
Species: Human
Sample Types: Whole Tissue
Applications: IHCY Kondo et al. (2021), L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus JCI Insight, 6(14).
PMID: 34291736 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotSJ Dicken et al. (2021), Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2 bioRxiv : the preprint server for biology, 0(0).
PMID: 33791702 -
Species: Human
Sample Types: Organoids
Applications: IHCX Duan et al. (2021), An airway organoid-based screen identifies a role for the HIF1alpha-glycolysis axis in SARS-CoV-2 infection Cell Reports, 37(6):109920.
PMID: 34731648 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotSP Shukla et al. (2021), "Molecular Masks" for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry International Journal of Molecular Sciences, 22(16).
PMID: 34445669 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryCH Chen et al. (2021), Deletion of ER-retention Motif on SARS-CoV-2 Spike Protein Reduces Cell Hybrid During Cell-cell Fusion Research square, 0(0).
PMID: 33851149 -
Species: Human
Sample Types: Whole Cells
Applications: ICCAZ Mykytyn et al. (2021), SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site Elife, 10(0).
PMID: 33393462 -
Species: Human
Sample Types: Whole Cells
Applications: ICCS Singh et al. (2021), SARS-CoV-2 and its variants of concern infect human conjunctival epithelial cells and induce differential antiviral innate immune response The ocular surface, 0(0).
PMID: 34583089 -
Species: Human
Sample Types: Whole Cells
Applications: ICCX Yin et al. (2021), MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells Cell Reports, 34(2):108628.
PMID: 33440148 -
Species: Mesocricetus auratus (Hamster)
Sample Types: Whole Cells
Applications: Flow CytometryH Chu et al. (2021), Host and viral determinants for efficient SARS-CoV-2 infection of the human lung Nature Communications, 12(1):134.
PMID: 33420022 -
Species: Human
Sample Types: Whole Cells
Applications: ICCC Blume et al. (2021), A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection Nature Genetics, 0(0).
PMID: 33432184 -
Species: Transgenic Mouse
Sample Types: Cell Lysates
Applications: Western BlotMW Ku et al. (2021), Brain Cross-Protection against SARS-CoV-2 Variants by a Lentiviral Vaccine in New Transgenic Mice Embo Molecular Medicine, 0(0):e14459.
PMID: 34647691 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotSB Biering et al. (2021), SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-beta signaling bioRxiv : the preprint server for biology, 0(0).
PMID: 34931188 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryJ Wang et al. (2021), SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells Cell Discovery, 7(1):119.
PMID: 34903715 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryL Nguyen et al. (2021), Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2 Nature Chemical Biology, 0(0).
PMID: 34754101 -
Species: Human
Sample Types: Organoids
Applications: IHCL Helms et al. (2021), Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations JCI Insight, 0(0).
PMID: 34767537 -
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot, `R Wang et al. (2020), Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses bioRxiv : the preprint server for biology, 0(0).
PMID: 32995787 -
Species: Human
Sample Types: Organoid
Applications: NeutralizationE Song et al. (2020), Neuroinvasion of SARS-CoV-2 in human and mouse brain bioRxiv : the preprint server for biology, 0(0).
PMID: 32935108 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotT Azad et al. (2020), Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization Membranes (Basel), 10(9).
PMID: 32872641 -
Species: Human
Sample Types: Whole Cells
Applications: ICCY Han et al. (2020), Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids bioRxiv, 0(0).
PMID: 32511403 -
Species: Human
Sample Types: Whole Tissue
Applications: IHCIT Lee et al. (2020), Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers medRxiv, 0(0).
PMID: 32511516 -
Species: Human
Sample Types: Protein
Applications: Western BlotL Casciola-R et al. (2020), IgM autoantibodies recognizing ACE2 are associated with severe COVID-19 medRxiv, 0(0).
PMID: 33083808 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryJ Huang et al. (2020), SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response Cell Stem Cell, 0(0).
PMID: 32979316 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotR Tandon et al. (2020), Effective screening of SARS-CoV-2 neutralizing antibodies in patient serum using lentivirus particles pseudotyped with SARS-CoV-2 spike glycoprotein Sci Rep, 10(1):19076.
PMID: 33154514 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryJ Huang et al. (2020), SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response bioRxiv, 0(0).
PMID: 32637964 -
Species: Mouse
Sample Types: Whole Tissue
Applications: IHCM Baratchian et al. (2020), Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2 bioRxiv, 0(0).
PMID: 33083800 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryKHD Crawford et al. (2020), Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays Viruses, 12(5).
PMID: 32384820 -
Species: Bat
Sample Types: Whole Cells
Applications: ICCJ Zhou et al. (2020), Infection of bat and human intestinal organoids by SARS-CoV-2 Nat. Med., 0(0).
PMID: 32405028 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotM Yang et al. (2020), Liraglutide Attenuates Non-Alcoholic Fatty Liver Disease in Mice by Regulating the Local Renin-Angiotensin System Front Pharmacol, 11(0):432.
PMID: 32322207 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryR Rathnasing et al. (2020), Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection bioRxiv, 0(0).
PMID: 32676603 -
Species: Mouse
Sample Types: Whole Tissue
Applications: IHCF Duan et al. (2020), Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq, 0(0).
PMID: 32839764 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryI Busnadiego et al. (2020), Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2 MBio, 11(5).
PMID: 32913009 -
Species: Human
Sample Types: Whole Cells
Applications: ICCJ Prévost et al. (2020), Cross-sectional evaluation of humoral responses against SARS-CoV-2 Spike bioRxiv : the preprint server for biology, 0(0).
PMID: 32577637 -
Species: Primate - Cercopithecus aethiops (African Green Monkey)
Sample Types: Whole Cells
Applications: NeutralizationHoffmann M et al. (2020), SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 181(0):1-10.
PMID: 32142651 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotL Pellegrini et al. (2020), SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids Cell Stem Cell, 0(0).
PMID: 33113348 -
Species: Primate
Sample Types: Whole Cells
Applications: ICCX Xie et al. (2020), A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19 Nat Commun, 11(1):5214.
PMID: 33060595 -
Species: Human
Sample Types: Whole Tissue
Applications: IHCIT Lee et al. (2020), ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs Nat Commun, 11(1):5453.
PMID: 33116139 -
Species: Human
Sample Types: Whole Tissue
Applications: IHCSP Sajuthi et al. (2020), Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium Nat Commun, 11(1):5139.
PMID: 33046696 -
Species: Human
Sample Types: Whole Cells
Applications: ICCW Rut et al. (2020), SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging Nat Chem Biol, 0(0).
PMID: 33093684 -
Species: Human
Sample Types: Organoid
Applications: ICCRM Samuel et al. (2020), Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell, 27(6):876-889.e12.
PMID: 33232663 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotJK Osan et al. (2020), Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in COPD bioRxiv, 0(0).
PMID: 33200131 -
Species: Rhesus Macaca (Macaque)
Sample Types: Whole Tissue
D Tian et al. (2019), Protective effects of the Francisella tularensis δpdpC mutant against its virulent parental strain SCHU P9 in Cynomolgus macaques Sci Rep, 9(1):9193.
PMID: 31235714 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotE Schrom et al. (2017), Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA Mol Ther Nucleic Acids, 7(0):350-365.
PMID: 28624211 -
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: IHCAleksandra Milewska (2016), HTCC: Broad Range Inhibitor of Coronavirus Entry PLoS ONE, 11(6):e0156552.
PMID: 27249425 -
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells
Applications: NeutralizationYu Y et al. (2016), Surface vimentin is critical for the cell entry of SARS-CoV. J Biomed Sci, 23(1):14.
PMID: 26801988 -
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Western BlotFengxia Xiao et al. (2016), Protein Kinase C-? Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells. Frontiers in Pharmacology, 0(0):1663-9812.
PMID: 27313531 -
Species: Mouse
Sample Types: Cell Lysates
Applications: Western BlotXiao F et al. (2014), Characterization of angiotensin-converting enzyme 2 ectodomain shedding from mouse proximal tubular cells. PLoS ONE, 9(1):e85958.
PMID: 24454948 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryHeurich A et al. (2014), TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. J Virol, 88(2):1293-307.
PMID: 24227843 -
Species: Bat
Sample Types: Whole Cells
Applications: IHCGe et al. (2013), Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature, 503(7477):535-8.
PMID: 24172901 -
Species: Human
Sample Types: Whole Tissue
Applications: IHCEckerle I et al. (2013), In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection. Virol J, 10(0):359.
PMID: 24364985 -
Species: Human
Sample Types: Whole Tissue
Applications: IHC-PBertram S et al. (2012), Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts. PLoS ONE, 7(4):e35876.
PMID: 22558251 -
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western BlotPohl M et al. (2010), Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron. J. Biol. Chem., 285(53):41935-46.
PMID: 20966072 -
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells
Applications: Flow CytometryLu Y et al. (2008), Lipid rafts are involved in SARS-CoV entry into Vero E6 cells. Biochem. Biophys. Res. Commun., 369(2):344-9.
PMID: 18279660 -
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Cell Lysates
Applications: Western BlotGlende J et al. (2008), Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2. Virology, 381(2):215-21.
PMID: 18814896 -
Species: Human
Sample Types: Plasma
Applications: NeutralizationEpelman S et al. (2008), Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system. J. Am. Coll. Cardiol., 52(9):750-4.
PMID: 18718423 -
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Cell Lysates
Applications: Western BlotInoue Y et al. (2007), Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted. J. Virol., 81(16):8722-9.
PMID: 17522231 -
Species: Human
Sample Types: Cell Lysates
Applications: Western BlotRen W et al. (2007), Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin. J. Virol., 82(4):1899-907.
PMID: 18077725 -
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells
Applications: NeutralizationRockx B et al. (2007), Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice. J. Virol., 81(14):7410-23.
PMID: 17507479 -
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells
Applications: ICCde Lang A et al. (2006), Interferon-gamma and interleukin-4 downregulate expression of the SARS coronavirus receptor ACE2 in Vero E6 cells. Virology, 353(2):474-81.
PMID: 16860835 -
Species: Human
Sample Types: Whole Cells
Applications: ICCTseng CT et al. (2005), Apical entry and release of severe acute respiratory syndrome-associated coronavirus in polarized Calu-3 lung epithelial cells. J. Virol., 79(15):9470-9.
PMID: 16014910 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryHofmann H et al. (2004), Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor. Biochem. Biophys. Res. Commun., 319(4):1216-21.
PMID: 15194496 -
Species: Human
Sample Types: Whole Cells
Applications: Flow CytometryOu X et al. (0), Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat Commu11(1):1620.
PMID: 32221306
There are no citations that match your criteria.
Customer Reviews (2)
Customer Images
-
Application: ICC/IFSample Tested: Stimulated Human Bronchial Epithelial Cell Line (BEAS-2B)Species: HumanVerified Customer | Posted 03/09/2021
-
Application: WBSample Tested: Blood mononuclear cells (PBMCs),Human CD34+ CellsSpecies: HumanVerified Customer | Posted 08/12/2016
There are no reviews that match your criteria.