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ACE-2: Small Molecules and Peptides
Angiotensin converting enzyme 2 (ACE-2), also known as ACEH (ACE homolog), is an integral membrane protein and a zinc metalloprotease of the ACE family. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase.
ACE-2 also serves as the receptor for the SARS-CoV and SARS-CoV-2 viruses. Binding of the S1 domain of the SARS Coronavirus Spike protein to ACE-2 initiates viral entry into the host cell. Recently, this interaction between SARS-CoV-2 and ACE-2 has become an area of intense therapeutic interest to develop treatments against COVID-19.
11 results for "ACE-2 Small Molecules and Peptides" in Products
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ACE-2: Small Molecules and Peptides
Angiotensin converting enzyme 2 (ACE-2), also known as ACEH (ACE homolog), is an integral membrane protein and a zinc metalloprotease of the ACE family. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase.
ACE-2 also serves as the receptor for the SARS-CoV and SARS-CoV-2 viruses. Binding of the S1 domain of the SARS Coronavirus Spike protein to ACE-2 initiates viral entry into the host cell. Recently, this interaction between SARS-CoV-2 and ACE-2 has become an area of intense therapeutic interest to develop treatments against COVID-19.
11 results for "ACE-2 Small Molecules and Peptides" in Products
Potent vasoconstrictor peptide
| Purity : | ≥95% (HPLC) |
Potent and selective angiotensin-converting enzyme 2 (ACE2) inhibitor
| Chemical Name : | N-[(1S)-1-Carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-L-histidine |
| Purity : | ≥98% (HPLC) |
HIF-PH inhibitor; erythropoietic
| Alternate Names : | FG 4592 |
| Chemical Name : | N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine |
| Purity : | ≥98% (HPLC) |
ACE2 derived peptide; binds SARS-CoV-2 spike protein receptor binding domain
| Purity : | ≥95% (HPLC) |
Highly potent inhibitor of SARS-CoV Spike (S) protein and ACE2 interaction
| Purity : | ≥95% (HPLC) |
Pan-histone deacetylase inhibitor
| Chemical Name : | (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide |
| Purity : | ≥98% (HPLC) |
Potent TRPV1 antagonist; also antioxidant; activates Nrf2/ARE signaling
| Chemical Name : | 2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one |
| Purity : | ≥98% (HPLC) |
Non-peptide, competitive angiotensin-converting enzyme (ACE) inhibitor
| Chemical Name : | (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid |
| Purity : | ≥99% (HPLC) |
Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation
| Alternate Names : | CP 62993 |
| Chemical Name : | 13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one |
| Purity : | ≥99% (HPLC) |
