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Secretase Inhibitors: Small Molecules and Peptides

Many membrane proteins also occur as in soluble forms due to proteolytic cleavage by secretases. alpha-, beta-, and gamma-secretases are best known for their cleavage of APP, the protein precursor of amyloid beta peptide (A beta), a major component of Alzheimer's disease plaques. Cleavage of APP by the beta- and gamma-secretases generates the Abeta peptide, while cleavage of APP by the alpha-secretase precludes the cleavage by the beta-secretase and prevents A beta production. The major candidates for the alpha-secretase are ADAM17/TACE, ADAM10, and ADAM9. BACE-1 is the major beta-secretase, although BACE-2 and Cathepsins D and E also have beta-secretase activity. The gamma-secretase is a multi-protein complex consisting of presenilin, nicastrin, APH-1, and PEN-2.

12 results for "Secretase Inhibitors Small Molecules and Peptides" in Products

Secretase Inhibitors: Small Molecules and Peptides

Many membrane proteins also occur as in soluble forms due to proteolytic cleavage by secretases. alpha-, beta-, and gamma-secretases are best known for their cleavage of APP, the protein precursor of amyloid beta peptide (A beta), a major component of Alzheimer's disease plaques. Cleavage of APP by the beta- and gamma-secretases generates the Abeta peptide, while cleavage of APP by the alpha-secretase precludes the cleavage by the beta-secretase and prevents A beta production. The major candidates for the alpha-secretase are ADAM17/TACE, ADAM10, and ADAM9. BACE-1 is the major beta-secretase, although BACE-2 and Cathepsins D and E also have beta-secretase activity. The gamma-secretase is a multi-protein complex consisting of presenilin, nicastrin, APH-1, and PEN-2.

12 results for "Secretase Inhibitors Small Molecules and Peptides" in Products

Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

γ-secretase inhibitor; induces neuronal differentiation

DAPT synthesized to Ancillary Material Grade

γ-secretase inhibitor; inhibits Notch pathway

Potent γ-secretase inhibitor

DBZ synthesized to Ancillary Material Grade

Potent and selective γ-secretase inhibitor

Highly potent γ-secretase inhibitor; orally bioavailable

Potent γ-secretase inhibitor

γ-secretase inhibitor; attenuates amyloid plaque deposition

Inhibitor of γ-secretase-mediated βAPP processing

BACE1 and BACE2 inhibitor

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