Sign In / Register
Secretase Inhibitors Products
Many membrane proteins also occur as in soluble forms due to proteolytic cleavage by secretases. alpha-, beta-, and gamma-secretases are best known for their cleavage of APP, the protein precursor of amyloid beta peptide (A beta), a major component of Alzheimer's disease plaques. Cleavage of APP by the beta- and gamma-secretases generates the Abeta peptide, while cleavage of APP by the alpha-secretase precludes the cleavage by the beta-secretase and prevents A beta production. The major candidates for the alpha-secretase are ADAM17/TACE, ADAM10, and ADAM9. BACE-1 is the major beta-secretase, although BACE-2 and Cathepsins D and E also have beta-secretase activity. The gamma-secretase is a multi-protein complex consisting of presenilin, nicastrin, APH-1, and PEN-2.
12 results for "Secretase Inhibitors" in Products
Product Action
Conjugates
Low Endotoxin
Sample Size
Citations
Reviews
Secretase Inhibitors Products
Many membrane proteins also occur as in soluble forms due to proteolytic cleavage by secretases. alpha-, beta-, and gamma-secretases are best known for their cleavage of APP, the protein precursor of amyloid beta peptide (A beta), a major component of Alzheimer's disease plaques. Cleavage of APP by the beta- and gamma-secretases generates the Abeta peptide, while cleavage of APP by the alpha-secretase precludes the cleavage by the beta-secretase and prevents A beta production. The major candidates for the alpha-secretase are ADAM17/TACE, ADAM10, and ADAM9. BACE-1 is the major beta-secretase, although BACE-2 and Cathepsins D and E also have beta-secretase activity. The gamma-secretase is a multi-protein complex consisting of presenilin, nicastrin, APH-1, and PEN-2.
12 results for "Secretase Inhibitors" in Products
Gamma γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
| Chemical Name : | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester |
| Purity : | ≥99% (HPLC) |
γ-secretase inhibitor; induces neuronal differentiation
| Alternate Names : | γ-Secretase Inhibitor XXI |
| Chemical Name : | N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
| Purity : | ≥98% (HPLC) |
Catalog #:
TB2634-RMU
DAPT synthesized to Ancillary Material Grade
| Chemical Name : | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine 1,1-dimethylethyl ester |
| Purity : | ≥99% |
γ-secretase inhibitor; inhibits Notch pathway
| Alternate Names : | Dibenzazepine |
| Chemical Name : | N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
| Purity : | ≥98% (HPLC) |
Catalog #:
5751
Potent γ-secretase inhibitor
| Chemical Name : | (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide |
| Purity : | ≥98% (HPLC) |
Catalog #:
TB4489-RMU
DBZ synthesized to Ancillary Material Grade
| Chemical Name : | N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
| Purity : | ≥98% |
Potent and selective γ-secretase inhibitor
| Alternate Names : | L 458, γ-Secretase Inhibitor X |
| Chemical Name : | (5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide |
| Purity : | ≥97% (HPLC) |
Catalog #:
6363
Highly potent γ-secretase inhibitor; orally bioavailable
| Alternate Names : | BMS-708163 |
| Chemical Name : | (2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide |
| Purity : | ≥98% (HPLC) |
Potent γ-secretase inhibitor
| Chemical Name : | 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid |
| Purity : | ≥98% (HPLC) |
γ-secretase inhibitor; attenuates amyloid plaque deposition
| Chemical Name : | N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide |
| Purity : | ≥99% (HPLC) |
Catalog #:
2677
Inhibitor of γ-secretase-mediated βAPP processing
| Chemical Name : | 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran |
| Purity : | ≥99% (HPLC) |
Catalog #:
7659
BACE1 and BACE2 inhibitor
| Chemical Name : | N-[3-[(5R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide |
| Purity : | ≥98% (HPLC) |
