PF 3084014 hydrobromide

Name: PF 3084014 hydrobromide
Brand: Tocris Bioscience
SKU: 5751

Tocris Bioscience a Bio-Techne Brand

Catalog # 5751

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Key Product Details

Description:	Potent γ-secretase inhibitor
Chemical Name:	(2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	651.47

View Full Technical Details for PF 3084014 hydrobromide

Biological Activity for PF 3084014 hydrobromide

PF 3084014 hydrobromide is a potent γ-secretase inhibitor (IC₅₀ values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 3084014 hydrobromide

M. Wt	651.47
Formula	C₂₇H₄₁F₂N₅O.HBr
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1962925-29-6
PubChem ID	121513889
InChi Key	LXEYYZYDWLAIPW-KBVFCZPLSA-N
Smiles	O=C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)[C@H](CCC)N[C@H]2CCC1=CC(F)=CC(F)=C1C2.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 3084014 hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	6.51	10 with gentle warming
	DMSO	65.15	100

Preparing Stock Solutions for PF 3084014 hydrobromide

The following data is based on the product molecular weight 651.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.53 mL	7.67 mL	15.35 mL
5 mM	0.31 mL	1.53 mL	3.07 mL
10 mM	0.15 mL	0.77 mL	1.53 mL
50 mM	0.03 mL	0.15 mL	0.31 mL

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Reconstitution Calculator

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References for PF 3084014 hydrobromide

References are publications that support the biological activity of the product.

Lanz Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 2010 PMID: 20363853

Citations for PF 3084014 hydrobromide

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