PF 3084014 hydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 5751
Potent γ-secretase inhibitor
Product Description
PF 3084014 hydrobromide is a potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
651.47
Formula
C27H41F2N5O.HBr
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide
CAS Number
1962925-29-6
PubChem ID
121513889
InChI Key
LXEYYZYDWLAIPW-KBVFCZPLSA-N
SMILES
O=C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)[C@H](CCC)N[C@H]2CCC1=CC(F)=CC(F)=C1C2.Br.Br
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 6.51 | 10 with gentle warming | |
| DMSO | 65.15 | 100 |
Preparing Stock Solutions
for PF 3084014 hydrobromide
The following data is based on the product molecular weight 651.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.53 mL | 7.67 mL | 15.35 mL |
| 5 mM | 0.31 mL | 1.53 mL | 3.07 mL |
| 10 mM | 0.15 mL | 0.77 mL | 1.53 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.31 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lanz Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014. J.Pharmacol.Exp.Ther. 2010 PMID: 20363853
Product Specific Notices for PF 3084014 hydrobromide
For research use only
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