Key Product Details
Description: | γ-secretase inhibitor; inhibits Notch pathway |
Alternative Names: | Dibenzazepine, YO-01027 |
Chemical Name: | N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 463.48 |
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Citations for DBZ (11)
Citations are publications that use Bio-Techne products. Selected citations for DBZ include:
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Page et al.
(2019)
Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis.
Cell Rep.
27:3139
PMID: 31189101 -
Yung et al.
(2019)
Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals.
Nat.Commun..
10:4647
PMID: 31604927 -
Santos et al.
(2019)
Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity.
Nat.Commun..
10:4407
PMID: 31562298 -
Khan et al.
(2018)
The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.
J Clin Invest.
128:1326
PMID: 29346117 -
Chen et al.
(2018)
Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture.
Proc Natl Acad Sci U S A.
115:E11671
PMID: 30487219 -
Marshall et al.
(2018)
Analysis of the Intrinsic Self-Organising Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial Cells.
Bioengineering (Basel).
5
PMID: 30373192 -
Bi et al.
(2016)
Stage-specific effects of Notch activation during skeletal myogenesis.
Elife.
5
PMID: 27644105 -
Ihara et al.
(2016)
TGF-β Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota.
J Immunol.
196:4603
PMID: 27183608 -
Bi et al.
(2016)
Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice.
J Exp Med.
213:2019
PMID: 27573812 -
Bi et al.
(2014)
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity.
Nat Med.
20:911
PMID: 25038826 -
Shah et al.
(2013)
The role of Notch and γ-secretase inhibition in an ovarian cancer model.
J Reprod Dev.
33:801
PMID: 23482747
There are no citations that match your criteria.
Customer Reviews for DBZ (1)
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Species: MouseAssay Type: In VivoCell Line/Tissue: iPSCsDifferentiation of hiPSCs into optic progenitor cells.For obtaining a higher solubility, I recommend warming at 37°C.
There are no reviews that match your criteria.