BMS 299897

Name: BMS 299897
Brand: Tocris Bioscience
SKU: 2870
Rating: 5 (2 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 2870

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(2)

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Key Product Details

Description:	Potent γ-secretase inhibitor
Chemical Name:	2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	511.94

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Biological Activity for BMS 299897

BMS 299897 is an orally active, potent γ-secretase inhibitor (IC₅₀ = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC₅₀ values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Exhibits no Notch toxicity. Brain penetrant.

Compound Libraries for BMS 299897

BMS 299897 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BMS 299897

M. Wt	511.94
Formula	C₂₄H₂₁ClF₃NO₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	290315-45-6
PubChem ID	11249248
InChi Key	IZAOBRWCUGOKNH-OAHLLOKOSA-N
Smiles	FC1=CC=[C@@]([C@H](N(C3=CC(F)=CC=C3F)S(C2=CC=C(Cl)C=C2)(=O)=O)C)C(CCCC(O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 299897

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.19	100
	ethanol	51.19	100

Preparing Stock Solutions for BMS 299897

The following data is based on the product molecular weight 511.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.77 mL	19.53 mL
5 mM	0.39 mL	1.95 mL	3.91 mL
10 mM	0.20 mL	0.98 mL	1.95 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

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References for BMS 299897

References are publications that support the biological activity of the product.

Goldstein Ex vivo occupancy of the γ-secretase inhibitors correlates with brain β-amyloid peptide reduction in Tg2576 mice. J.Pharmacol.Exp.Ther. 2007 PMID: 17640949
Barten Dynamics of β-Amyloid reductions in brain, cerebrospinal fluid, and plasma of β-amyloid precursor protein transgenic mice treated with a γ-secretase inhibitor. J.Pharmacol.Exp.Ther. 2005 PMID: 15452193
Anderson Reductions in β-amyloid concentrations in vivo by the γ-secretase inhibitors BMS-289948 and BMS-299897. Biochem.Pharmacol. 2005 PMID: 15670587

Citations for BMS 299897 (2)

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Citations are publications that use Bio-Techne products. Selected citations for BMS 299897 include:

Liu et al. (2018) APP upregulation contributes to retinal ganglion cell degeneration via JNK3. Cell Death Differ. 25:661
PMID: 29238071
Pitt et al. (2017) Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers. Mol Biol Cell. 28:2623
PMID: 28963439

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Customer Reviews for BMS 299897 (2)

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works well

Name: Anonymous

Species: Rat

Assay Type: In Vitro

Cell Line/Tissue: Hippocampal neuron

gamma -secretase (100 nM BMS 299897 and 250 nM DAPT)

PMID: PMID: 28963439
BMS as a inhibitor treatment is good for Hippocampal neuron

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: Hippocampal neuron

Using more specific inhibitors, we ruled out the involvement of gamma -secretase (100 nM BMS 299897 and 250 nM DAPT) or matrix metalloproteinases 1, 2, 3, 7, 9, 14, and 17 (0.1–1 μM batimastat and marimastat), as their inhibitors failed to alter A beta O release

PMID: 28963439

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Product Documents for BMS 299897

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.